{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:52:33Z","timestamp":1791276753514,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["021397"],"award-info":[{"award-number":["021397"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["130239"],"award-info":[{"award-number":["130239"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009429","name":"Israel National Road Safety Authority","doi-asserted-by":"publisher","award":["F31DK139757\u201003"],"award-info":[{"award-number":["F31DK139757\u201003"]}],"id":[{"id":"10.13039\/100009429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The role of amylin signalling in energy balance control has been understudied in calcitonin receptor (CTR) expressing nuclei such as the mesopontine laterodorsal tegmental nucleus (LDTg). Our lab has shown that LDTg amylin signalling reduces feeding and body weight, but the neuronal phenotype and downstream targets of LDTg\n                      <jats:sup>CTR<\/jats:sup>\n                      cells mediating these feeding effects remain unknown. Given that the LDTg has been established to modulate reward and motivated behaviours, we hypothesize that LDTg amylin signalling influences energy balance via direct modulation of VTA activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Here, we combine circuit tracing, immunohistochemical, fluorescent in\u00a0situ hybridization, pharmacological, behavioural and chemogenic approaches to phenotype LDTg\n                      <jats:sup>CTR<\/jats:sup>\n                      neurons and explore LDTg\n                      <jats:sup>CTR<\/jats:sup>\n                      \u2009\u2192\u2009VTA neurons as a functional energy balance control pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LDTg CTR+ neurons are a heterogenous population composed of glutamatergic and GABAergic neurons that project to the VTA in both mice and rats. Our results show that chemogenetic activation of LDTg\n                      <jats:sup>CTR<\/jats:sup>\n                      neurons reduces c\u2010Fos expression in the VTA, suggesting a mechanism via which LDTg amylin signalling influences energy balance by modulation of downstream VTA signalling. In support of this, our experiments show that unilateral circuit specific (LDTg\u2009\u2192\u2009VTA)\n                      <jats:italic>Calcr<\/jats:italic>\n                      knockdown was sufficient to attenuate the anorexigenic effects of peripherally delivered salmon calcitonin at 6\u2010 and 12\u2009h post injection. Lastly, we demonstrate that projection\u2010specific chemogenetic excitation of this LDTg\n                      <jats:sup>CTR<\/jats:sup>\n                      \u2009\u2192\u2009VTA pathway is sufficient to reduce food intake and body weight in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conslusion<\/jats:title>\n                    <jats:p>Altogether, these findings anatomically and functionally characterize a new amylin\/CTR signalling pathway, further establishing the LDTg as a potential target for novel obesity pharmacotherapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71415","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:21:07Z","timestamp":1791274867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amylin Receptor Signalling in the Laterodorsal Tegmental Nucleus Controls Food Intake Through Projections to the Ventral Tegmental Area"],"prefix":"10.1111","author":[{"given":"Marcos J.","family":"Sanchez Navarro","sequence":"first","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Fortin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-6551","authenticated-orcid":false,"given":"Matthew R.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2147\/DMSO.S141235","article-title":"Reasons for Discontinuation of GLP1 Receptor Agonists: Data From a Real\u2010World Cross\u2010Sectional Survey of Physicians and Their Patients With Type 2 Diabetes","volume":"10","author":"Sikirica M. 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