{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:45:36Z","timestamp":1791859536833,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018542","name":"Irish Endocrine Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Birthweight of\n                      <jats:italic>HNF1A<\/jats:italic>\n                      \u2010affected offspring is largely similar to the background population with rarely reported cases of large for gestational age (LGA) and neonatal hypoglycaemia (NH). Conventional clinical management of pre\u2010gestational diabetes appears to be sufficient in managing\n                      <jats:italic>HNF1A<\/jats:italic>\n                      \u2010affected women in pregnancy. This study aims to evaluate pregnancy outcomes and review glucose management in a cohort with HNF1A\u2010MODY.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>This is a retrospective review of 183 offspring (142 maternal and 41 paternal) of 73 parents with confirmed HNF1A\u2010MODY. Data were obtained from maternal\/paternal recall and\/or review of maternity charts. Variables included glycaemic treatment, HbA1c, fructosamine, gestational weight gain, neonatal birthweight, gestation, incidence of NH, and offspring genotype status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Maternal offspring had a higher incidence of LGA (39.4% vs. 15%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). LGA was associated with maternal dysglycaemia independent of neonatal mutation status. Rate of LGA was lower with insulin treatment compared to diet (35.1% vs. 64.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Subgroup analysis of insulin treated pregnancies showed LGA was associated with higher mean capillary glucose (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934), third trimester insulin doses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933), HbA1c (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934) and maternal gestational weight gain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931). Weight adjusted total daily dose of insulin was 0.61 unit\/kg\/day (0.49\u20130.62) in Trimester 3 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926). Persistent NH was more prevalent in maternally inherited cases with dysglycaemia (8 vs. 0 offspring,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.067).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Large birthweight and NH occur in offspring of parents with\n                      <jats:italic>HNF1A<\/jats:italic>\n                      mutations. These sequelae are more frequent and clinically significant in maternally inherited cases. It is prudent to counsel relevant obstetric and neonatal teams around specific perinatal concerns to reduce potential morbidity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71416","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:55:48Z","timestamp":1791856548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycaemic Management and Pregnancy Outcomes in\n                    <scp>HNF1A<\/scp>\n                    \u2010\n                    <scp>MODY<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-9711","authenticated-orcid":false,"given":"M. T.","family":"Crowley","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"University College Dublin  Dublin Ireland"},{"name":"Rotunda Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"Rotunda Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sanchez\u2010Lechuga","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Rotunda Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hatunic","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"National Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kinsley","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Mater Misericordiae University Hospital  Dublin Ireland"},{"name":"The Coombe Women and Children's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bacon","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Colclough","sequence":"additional","affiliation":[{"name":"Exeter Genomics Laboratory Royal Devon University Healthcare NHS Foundation Trust  Exeter Devon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kennelly","sequence":"additional","affiliation":[{"name":"Rotunda Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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