{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:50:59Z","timestamp":1791510659660,"version":"4.3.4"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucocorticoids (GCs) commonly induce glycaemic disturbance, from transient steroid\u2010induced hyperglycaemia to steroid\u2010induced diabetes and contribute to post\u2010transplant diabetes mellitus (PTDM). Insulin remains the standard treatment for GC\u2010induced glycaemic dysregulation. Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) have a mechanistic rationale here, but their efficacy and safety in GC\u2010induced dysglycaemia have not been systematically appraised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted in accordance with PRISMA 2020 guidelines (registration number: CRD420251183082). Embase, PubMed\/MEDLINE and the Cochrane Library were searched up to May 2026. A structured narrative synthesis was the primary method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen studies were included, predominantly retrospective cohort studies; 10 enrolled solid organ transplant recipients with PTDM or pre\u2010existing type 2 diabetes. GLP\u20101 RA therapy, either as monotherapy or as an adjunct to insulin, was associated with reductions in HbA1c and body weight, and a low rate of hypoglycaemia in the majority of included studies. GLP\u20101 RAs led to insulin dose reduction or discontinuation, reducing injection frequency and treatment burden. Five studies contributed to at least one pooled estimate, and no outcome was informed by more than three studies; given substantial heterogeneity and very low GRADE certainty, these estimates are exploratory and are presented in Supplementary Material 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individual studies reported reductions in HbA1c, body weight and insulin dose, with a low rate of hypoglycaemia episodes. However, available data specific to GC\u2010induced dysglycaemia remain insufficient. Prospective controlled trials with explicit characterisation of GC exposure are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71418","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:24:47Z","timestamp":1791509087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>GLP<\/scp>\n                    \u20101 Receptor Agonist Therapy for Glucocorticoid\u2010Induced Dysglycaemia: A Systematic Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6320-4797","authenticated-orcid":false,"given":"Aleksandra","family":"J\u0119drasek","sequence":"first","affiliation":[{"name":"Department of Diabetology and Internal Medicine Medical University of Warsaw  Warsaw Poland"},{"name":"Doctoral School, Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktoria","family":"Ulicka","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Lisowska","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fabia\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Internal Diseases Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Ma\u0142yszko","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Internal Diseases Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-8885","authenticated-orcid":false,"given":"Leszek","family":"Czupryniak","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00683-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16532"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1177\/20503121241235056","article-title":"Nationwide Prevalence of Glucocorticoid Prescriptions Over 17\u2009Years and Osteoporosis Prevention Among Long\u2010Term Users","volume":"12","author":"Bjornsdottir H. 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