{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:39:06Z","timestamp":1792467546892,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To systematically review and quantitatively synthesize within\u2010group changes in skeletal muscle strength following semaglutide treatment in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This PRISMA 2020 systematic review was registered in PROSPERO (CRD420251185935). MEDLINE, Embase, CENTRAL, LILACS and Google Scholar were searched through 20 August 2026, without language restrictions. Eligible studies included adults treated with semaglutide reporting quantitative skeletal muscle strength outcomes, including handgrip and knee extension strength. Randomized, non\u2010randomized and uncontrolled before\u2010after studies were included. The primary meta\u2010analysis pooled within\u2010group changes in handgrip strength from baseline to the longest available follow\u2010up of semaglutide\u2010only arms using a random\u2010effects model. Knee extension strength was summarized descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen reports represented eleven studies, all assessing handgrip strength; one small randomized trial also assessed knee extension strength. Ten studies (660 semaglutide\u2010treated participants) contributed to the primary meta\u2010analysis of uncontrolled within\u2010group changes, showing a nonsignificant pooled handgrip strength change (\u22120.16\u2009kgf; 95% confidence interval: \u22121.98 to 1.65), with substantial heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200990.8%) and a 95% prediction interval from \u22125.96 to 5.63\u2009kgf. Duration\u2010stratified and sensitivity analyses were also nonsignificant. Individual study findings were heterogeneous. Certainty was very low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Available evidence is insufficient to determine whether semaglutide is associated with changes in handgrip strength because the principal synthesis was based on uncontrolled within\u2010group changes, with very low certainty and significant heterogeneity. These findings do not establish strength preservation or a causal treatment effect. More robust comparative studies with standardized strength assessment and longer follow\u2010up are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71432","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:51:14Z","timestamp":1792464674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Muscle Strength Following Semaglutide Treatment in Adults: A Systematic Review With Meta\u2010Analysis of Handgrip Strength"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3841-5506","authenticated-orcid":false,"given":"Lu\u00eds Guilherme","family":"Machado","sequence":"first","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4348-3319","authenticated-orcid":false,"given":"Pedro Henrique","family":"Siedschlag Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Tasca Petroski","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo Lucas","family":"Lopes Costa","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5934-8488","authenticated-orcid":false,"given":"Let\u00edcia","family":"Vieira dos Santos Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Victor","family":"Ramos Da Cruz","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7986-8317","authenticated-orcid":false,"given":"Graziela","family":"De Luca Canto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Evidence\u2010Based Health, Escola Paulista de Medicina Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8073-5837","authenticated-orcid":false,"given":"Alexandre","family":"Hohl","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-9842","authenticated-orcid":false,"given":"Marcelo Fernando","family":"Ronsoni","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-1603","authenticated-orcid":false,"given":"Simone","family":"van de Sande\u2010Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"World Obesity Atlas 2025","author":"World Obesity Federation","year":"2025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01210\u20108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u20101678"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.04.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00213\u20100"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2500969"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc26\u2010S008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010024\u201001041\u20104"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.067676"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4467"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.1.72"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2025.01.009"},{"key":"e_1_2_9_18_1","unstructured":"ClinicalTrials.gov \u201cNCT05302596: Semaglutide Use in Elderly Obese Patients \u201d(2022) Cochrane Central Register of Controlled Trials CN\u201002391887 https:\/\/clinicaltrials.gov\/study\/NCT05302596."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igae098.1054"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000001334"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1674308"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000545547"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70141"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S531778"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14122414"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214673"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000545547"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010023\u201001686\u2010z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_9_30_1","volume-title":"Revised Cochrane Risk\u2010of\u2010Bias Tool for Randomized Trials (RoB 2)","author":"Higgins J. P. T.","year":"2019"},{"key":"e_1_2_9_31_1","unstructured":"Risk of Bias Tools \u201cRisk Of Bias in Non\u2010Randomized Studies\u2010of Interventions Version 2 (ROBINS\u2010I V2) Tool \u201d(2025) https:\/\/www.riskofbias.info\/welcome\/robins\u2010i\u2010v2."},{"key":"e_1_2_9_32_1","unstructured":"National Heart Lung and Blood Institute \u201cQuality Assessment Tool for Before\u2010After (Pre\u2010Post) Studies With No Control Group. Study Quality Assessment Tools \u201d(2021) https:\/\/www.nhlbi.nih.gov\/health\u2010topics\/study\u2010quality\u2010assessment\u2010tools."},{"key":"e_1_2_9_33_1","volume-title":"R: A Language and Environment for Statistical Computing [Computer Software]","author":"R Core Team","year":"2024"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.31.75"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_36_1","volume-title":"GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations","author":"Sch\u00fcnemann H.","year":"2013"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70253"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202310_34169"},{"key":"e_1_2_9_39_1","unstructured":"O.Anyiam \u201cAn Examination Into the Effects of Very\u2010Low Calorie Diets and Glucagon\u2010Like Peptide\u20101 Receptor Agonists Individually or in Combination on Skeletal Muscle Metabolism and Glycaemic Outcomes in Individuals With Type 2 Diabetes Living With Obesity \u201dDissertation (University of Nottingham: 2025)."},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcle.2026.107364"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.70295"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010026\u201004204\u20100"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2025.101681"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls064"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518268"},{"key":"e_1_2_9_46_1","first-page":"277","volume-title":"Bridging the Evidence Gap in Obesity Prevention: A Framework to Inform Decision Making","author":"Institute of Medicine (US) Committee on an Evidence Framework for Obesity Prevention Decision Making","year":"2010"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12422"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13790"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2343092"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab048.030"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u201005065\u20108"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12984\u2010025\u201001845\u2010z"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24336"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112229"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:51:23Z","timestamp":1792464683000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":53,"alternative-id":["10.1111\/dom.71432"],"URL":"https:\/\/doi.org\/10.1111\/dom.71432","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"2026-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dom.71432"}}