{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:55:13Z","timestamp":1791881713159,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"ABSTRACT<\/jats:title>\n \n Aims<\/jats:title>\n Perirenal adipose tissue (PRAT) surrounds the kidney and may contribute to chronic kidney disease (CKD) progression. SGLT2 inhibitors have been associated with reductions in this depot, but PRAT has not been quantified under GLP\u20101RA\u2010based therapy in CKD. We assessed ultrasound\u2010measured PRAT thickness under both treatments and whether changes tracked weight loss.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Adults with CKD Stages 1\u20134 in the prospective ADIPO\u2010CKD inception cohort underwent ultrasound at baseline and at the 8\u2010month visit. PRAT thickness was the mean of right and left measurements; epicardial adipose tissue and body composition were also assessed. Patients received neither drug class (reference), SGLT2i or GLP\u20101RA\u2010based therapy. Follow\u2010up PRAT was analysed by covariance analysis adjusted for baseline.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 277 patients, 80 had paired studies (32 reference, 24 SGLT2i, 24 GLP\u20101RA\u2010based; body weight 46\u2013122\u2009kg). PRAT was unchanged in the reference group (+0.035\u2009cm,\n p<\/jats:italic>\n \u2009=\u20090.376) and decreased with SGLT2i (\u22120.273\u2009cm, \u221220.4%,\n p<\/jats:italic>\n \u2009=\u20090.0006) and GLP\u20101RA\u2010based therapy (\u22120.463\u2009cm, \u221236.2%,\n p<\/jats:italic>\n \u2009<\u20090.0001). Adjusted differences versus reference were \u22120.227\u2009cm (95% CI \u22120.417 to \u22120.036) and \u22120.433\u2009cm (\u22120.622 to \u22120.244); under multiple imputations, \u22120.218\u2009cm (\u22120.482 to +0.046) and \u22120.421\u2009cm (\u22120.693 to \u22120.149). GLP\u20101RA\u2010based therapy reduced body weight, fat mass and visceral fat area; SGLT2i only body weight, modestly. PRAT change correlated with none.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In CKD, both drug classes were associated with lower follow\u2010up PRAT, not explained by measured body\u2010composition change. Under multiple imputations, both estimates were essentially unchanged, though the SGLT2i interval included no difference. PRAT may represent a candidate depot\u2010specific target.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n ClinicalTrials.gov identifier: NCT07309094 (ADIPO\u2010CKD)<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.71441","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:35:56Z","timestamp":1791880556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of\n GLP<\/scp>\n \u2010\n 1RA<\/scp>\n \u2010Based and\n SGLT2<\/scp>\n Inhibitor Therapy on Perirenal Adipose Tissue in\n CKD<\/scp>\n Patients"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-6711","authenticated-orcid":false,"given":"Ana","family":"Checa\u2010Ros","sequence":"first","affiliation":[{"name":"Grupo de Investigacion en Enfermedades Cardiorrenales y Metab\u00f3licas, Departamento de Medicina y Cirugia, Facultad de Ciencias de la Salud Universidad Cardenal Herrera\u2010CEU, CEU Universities Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Arias\u2010Mutis","sequence":"additional","affiliation":[{"name":"Grupo de Investigacion en Enfermedades Cardiorrenales y Metab\u00f3licas, Departamento de Medicina y Cirugia, Facultad de Ciencias de la Salud Universidad Cardenal Herrera\u2010CEU, CEU Universities Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owahabanun\u2010Joshua","family":"Okojie","sequence":"additional","affiliation":[{"name":"Grupo de Investigacion en Enfermedades Cardiorrenales y Metab\u00f3licas, Departamento de Medicina y Cirugia, Facultad de Ciencias de la Salud Universidad Cardenal Herrera\u2010CEU, CEU Universities Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Salvador","sequence":"additional","affiliation":[{"name":"Hospital Vithas Consuelo Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-891X","authenticated-orcid":false,"given":"Luis","family":"D'Marco","sequence":"additional","affiliation":[{"name":"Grupo de Investigacion en Enfermedades Cardiorrenales y Metab\u00f3licas, Departamento de Medicina y Cirugia, Facultad de Ciencias de la Salud Universidad Cardenal Herrera\u2010CEU, CEU Universities Valencia Spain"},{"name":"Hospital Vithas Consuelo Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136247"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaf218"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09380822"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403347"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201061590\u20106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm15103641"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116623"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2026.178523"},{"issue":"4","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2024","journal-title":"Kidney 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