{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:40:51Z","timestamp":1792464051731,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>Key Messages<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>GLP\u20101 receptor agonists and metabolic bariatric surgery are complementary tools in chronic obesity care, not simple substitutes.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Trial efficacy, real\u2010world effectiveness, durability, affordability, indirect costs and implementation capacity need separate assessment.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Surgery can produce durable weight loss and cardiometabolic benefit in selected patients, but requires operative capacity, multidisciplinary preparation, recovery time and lifelong nutritional and metabolic follow\u2010up.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Incretin\u2010based pharmacotherapy has transformed obesity treatment, but real\u2010world persistence, price, supply and clinical support remain central determinants of value.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Effective obesity pharmacotherapy usually requires long\u2010term continuation to sustain clinical benefit; inadequate response or treatment discontinuation should prompt an individualised transition plan rather than passive observation.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Policy should be tailored to local disease burden, primary\u2010care capacity, surgical services, medicines access, financing and equity constraints.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/dom.71450","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:34:34Z","timestamp":1792463674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Drugs or Surgery: Precision and Equity in Obesity Care"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6198-4352","authenticated-orcid":false,"given":"Ron T.","family":"Varghese","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele F.","family":"Petridis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-2072","authenticated-orcid":false,"given":"Nitin","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherian","family":"Varghese","sequence":"additional","affiliation":[{"name":"Prasanna School of Public Health Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Bernal\u2010Mizrachi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)02750\u20102"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010026\u201010383\u20100"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac071"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000066"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010026\u201004397\u20104"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102025\u2010005729"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2025.3590"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.57349"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2024.23332"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v16.i4.101731"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2026.103796"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000934"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2026.31371"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.71317"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i3.278"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i10.1587"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.17925\/HI.2024.18.1.1"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2026.102107"},{"key":"e_1_2_15_23_1","unstructured":"National Institute for Health and Care Excellence \u201cSemaglutide for Managing Overweight and Obesity. 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