{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:02:52Z","timestamp":1757311372497},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":648,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dis Esophagus"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1111\/dote.12162","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T14:59:49Z","timestamp":1385132389000},"page":"97-103","source":"Crossref","is-referenced-by-count":11,"title":["Homozygosity in the ApoE 4 polymorphism is associated with dysphagic symptoms in older adults"],"prefix":"10.1093","volume":"28","author":[{"given":"H.","family":"Mentz","sequence":"first","affiliation":[{"name":"Centre for Gastrointestinal Sciences, Institute of Inflammation and Repair; University of Manchester (part of the Manchester Academic Health Sciences Centre (MAHSC)); Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Horan","sequence":"additional","affiliation":[{"name":"Centre for Clinical and Cognitive Neuroscience, Institute of Brain, Behaviour and Mental Health; University of Manchester (part of the Manchester Academic Health Sciences Centre (MAHSC)); Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Payton","sequence":"additional","affiliation":[{"name":"Imaging, Genomics and Proteomics Research Group, Institute of Population Health; University of Manchester (part of the Manchester Academic Health Sciences Centre (MAHSC)); Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ollier","sequence":"additional","affiliation":[{"name":"Imaging, Genomics and Proteomics Research Group, Institute of Population Health; University of Manchester (part of the Manchester Academic Health Sciences Centre (MAHSC)); Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pendleton","sequence":"additional","affiliation":[{"name":"Centre for Clinical and Cognitive Neuroscience, Institute of Brain, Behaviour and Mental Health; University of Manchester (part of the Manchester Academic Health Sciences Centre (MAHSC)); Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Centre for Gastrointestinal Sciences, Institute of Inflammation and Repair; University of Manchester (part of the Manchester Academic Health Sciences Centre (MAHSC)); Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"10.1111\/dote.12162-BIB0001|dote12162-cit-0001","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/gps.2644","article-title":"The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes","volume":"26","author":"D'Onofrio","year":"2011","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1111\/dote.12162-BIB0002|dote12162-cit-0002","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1001\/archneurol.2011.155","article-title":"Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease","volume":"68","author":"Cruchaga","year":"2011","journal-title":"Arch Neurol"},{"key":"10.1111\/dote.12162-BIB0003|dote12162-cit-0003","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/0140-6736(93)91709-U","article-title":"Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases","volume":"342","author":"Saunders","year":"1993","journal-title":"Lancet"},{"key":"10.1111\/dote.12162-BIB0004|dote12162-cit-0004","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000017120","article-title":"Apolipoprotein E genetic variation and Alzheimer's disease. A meta-analysis","volume":"10","author":"Rubinsztein","year":"1999","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1111\/dote.12162-BIB0005|dote12162-cit-0005","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/gps.2643","article-title":"Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features","volume":"26","author":"Fritze","year":"2011","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1111\/dote.12162-BIB0006|dote12162-cit-0006","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMoa0809437","article-title":"Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect","volume":"361","author":"Caselli","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1111\/dote.12162-BIB0007|dote12162-cit-0007","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neurobiolaging.2009.02.003","article-title":"The effects of apolipoprotein E on non-impaired cognitive functioning: a meta-analysis","volume":"32","author":"Wisdom","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1111\/dote.12162-BIB0008|dote12162-cit-0008","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1037\/0882-7974.19.4.592","article-title":"Apolipoprotein E and cognitive performance: a meta-analysis","volume":"19","author":"Small","year":"2004","journal-title":"Psychol Aging"},{"key":"10.1111\/dote.12162-BIB0009|dote12162-cit-0009","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00455-001-0113-5","article-title":"Social and psychological burden of dysphagia: its impact on diagnosis and treatment","volume":"17","author":"Ekberg","year":"2002","journal-title":"Dysphagia"},{"key":"10.1111\/dote.12162-BIB0010|dote12162-cit-0010","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00455-011-9359-8","article-title":"Effects of carbonated liquids on oropharyngeal swallowing measures in people with neurogenic dysphagia","volume":"27","author":"Sdravou","year":"2011","journal-title":"Dysphagia"},{"key":"10.1111\/dote.12162-BIB0011|dote12162-cit-0011","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.pupt.2011.01.015","article-title":"Voluntary and reflex cough and the expiration reflex; implications for aspiration after stroke","volume":"24","author":"Widdicombe","year":"2011","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1111\/dote.12162-BIB0012|dote12162-cit-0012","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/PL00021290","article-title":"Screening for dysphagia and aspiration in acute stroke: a systematic review","volume":"16","author":"Perry","year":"2001","journal-title":"Dysphagia"},{"key":"10.1111\/dote.12162-BIB0013|dote12162-cit-0013","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11239-005-3205-5","article-title":"Thrombophilias and stroke: diagnosis, treatment, and prognosis","volume":"20","author":"Fields","year":"2005","journal-title":"J Thromb Thrombolysis"},{"key":"10.1111\/dote.12162-BIB0014|dote12162-cit-0014","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJMoa0808227","article-title":"Genetic determinants of response to clopidogrel and cardiovascular events","volume":"360","author":"Simon","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1111\/dote.12162-BIB0015|dote12162-cit-0015","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1468-1331.2011.03615.x","article-title":"Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International Studies","volume":"19","author":"Cramer","year":"2012","journal-title":"Eur J Neurol"},{"key":"10.1111\/dote.12162-BIB0016|dote12162-cit-0016","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0016-5085(00)70137-5","article-title":"Development and validation of a self-report symptom inventory to assess the severity of oral-pharyngeal dysphagia","volume":"118","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1111\/dote.12162-BIB0017|dote12162-cit-0017","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/13825580490511116","article-title":"The University of Manchester longitudinal study of cognition in normal healthy old age, 1983 through 2003","volume":"11","author":"Rabbitt","year":"2004","journal-title":"Aging Neuropsychol Cogn"},{"key":"10.1111\/dote.12162-BIB0018|dote12162-cit-0018","unstructured":"Evans O Singleton N Meltzer H Stewart R Prince M The Mental Health of Older People 2003"},{"key":"10.1111\/dote.12162-BIB0019|dote12162-cit-0019","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1093\/nar\/gni155","article-title":"Detection of ApoE E2, E3 and E4 alleles using MALDI-TOF mass spectrometry and the homogeneous mass-extend technology","volume":"33","author":"Ghebranious","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1111\/dote.12162-BIB0020|dote12162-cit-0020","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1442-2050.2011.01182.x","article-title":"Prevalence and symptom profiling of oropharyngeal dysphagia in a community dwelling of an elderly population: a self-reporting questionnaire survey","volume":"24","author":"Holland","year":"2011","journal-title":"Dis Esophagus"},{"key":"10.1111\/dote.12162-BIB0021|dote12162-cit-0021","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1212\/WNL.45.8.1446","article-title":"Intelligence and education as predictors of cognitive state in late life: a 50-year follow-up","volume":"45","author":"Plassman","year":"1995","journal-title":"Neurology"},{"key":"10.1111\/dote.12162-BIB0022|dote12162-cit-0022","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1600-0447.2006.00888.x","article-title":"The criterion validity of the Geriatric Depression Scale: a systematic review","volume":"114","author":"Wancata","year":"2006","journal-title":"Acta Psychiatr Scand"},{"key":"10.1111\/dote.12162-BIB0023|dote12162-cit-0023","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/ajpa.21298","article-title":"Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history","volume":"143","author":"Eisenberg","year":"2010","journal-title":"Am J Phys Anthropol"},{"key":"10.1111\/dote.12162-BIB0024|dote12162-cit-0024","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3233\/JAD-2010-1316","article-title":"Early deficits in cortical control of swallowing in Alzheimer's disease","volume":"19","author":"Humbert","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1111\/dote.12162-BIB0025|dote12162-cit-0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.pmr.2008.05.002","article-title":"Neural control of feeding and swallowing","volume":"19","author":"Mistry","year":"2008","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"10.1111\/dote.12162-BIB0026|dote12162-cit-0026","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ddrr.12","article-title":"The neurobiology of swallowing and dysphagia","volume":"14","author":"Miller","year":"2008","journal-title":"Dev Disabil Res Rev"},{"key":"10.1111\/dote.12162-BIB0027|dote12162-cit-0027","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s00455-004-0013-6","article-title":"Prevalence of dysphagia among community-dwelling elderly individuals as estimated using a questionnaire for dysphagia screening","volume":"19","author":"Kawashima","year":"2004","journal-title":"Dysphagia"},{"key":"10.1111\/dote.12162-BIB0028|dote12162-cit-0028","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1177\/0022034511422909","article-title":"Meta-analysis of dysphagia and aspiration pneumonia in frail elders","volume":"90","author":"Van der Maarel-Wierink","year":"2011","journal-title":"J Dent Res"},{"key":"10.1111\/dote.12162-BIB0029|dote12162-cit-0029","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/01.mcg.0000159272.88974.54","article-title":"Dysphagia in aging","volume":"39","author":"Achem","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1111\/dote.12162-BIB0030|dote12162-cit-0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2000-8384","article-title":"Optimal patterns of care in patients with chronic obstructive pulmonary disease","volume":"21","author":"Martin-Harris","year":"2000","journal-title":"Semin Speech Lang"},{"key":"10.1111\/dote.12162-BIB0031|dote12162-cit-0031","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/mp.2010.90","article-title":"The APOE varepsilon4 allele modulates brain white matter integrity in healthy adults","volume":"16","author":"Heise","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1111\/dote.12162-BIB0032|dote12162-cit-0032","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/dote.12162-BIB0033|dote12162-cit-0033","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0197-4580(00)00097-X","article-title":"The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models","volume":"21","author":"Horsburgh","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1111\/dote.12162-BIB0034|dote12162-cit-0034","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/gps.2621","article-title":"Synergistic associations of depression and apolipoprotein E genotype with incidence of dementia","volume":"26","author":"Kim","year":"2010","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1111\/dote.12162-BIB0035|dote12162-cit-0035","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1152\/ajpgi.2001.280.4.G531","article-title":"Swallow-related cortical activity maps are not specific to deglutition","volume":"280","author":"Kern","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1111\/dote.12162-BIB0036|dote12162-cit-0036","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/cercor\/7.1.86","article-title":"The autonomic-related cortex: pathology in Alzheimer's disease","volume":"7","author":"Chu","year":"1997","journal-title":"Cereb Cortex"},{"key":"10.1111\/dote.12162-BIB0037|dote12162-cit-0037","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1152\/jn.2001.85.2.938","article-title":"Cerebral cortical representation of automatic and volitional swallowing in humans","volume":"85","author":"Martin","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1111\/dote.12162-BIB0038|dote12162-cit-0038","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/1531-8249(199909)46:3<281::AID-ANA2>3.0.CO;2-L","article-title":"The functional neuroanatomy of voluntary swallowing","volume":"46","author":"Zald","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1111\/dote.12162-BIB0039|dote12162-cit-0039","first-page":"G219","article-title":"Cortical activation during human volitional swallowing: an event-related fMRI study","volume":"277","author":"Hamdy","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1111\/dote.12162-BIB0040|dote12162-cit-0040","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease","volume":"56","author":"Hyman","year":"1997","journal-title":"J Neuropathol Exp Neurol"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdote.12162","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/dote\/article-pdf\/28\/1\/97\/10398830\/dote0097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T20:21:22Z","timestamp":1564863682000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article-lookup\/doi\/10.1111\/dote.12162"}},"subtitle":["Genes and dysphagia in the elderly"],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.1111\/dote.12162","relation":{},"ISSN":["1120-8694"],"issn-type":[{"value":"1120-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,22]]}}}