{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:17:44Z","timestamp":1777051064196,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":116,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dis Esophagus"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1111\/dote.12374","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T05:07:45Z","timestamp":1431061665000},"page":"787-793","source":"Crossref","is-referenced-by-count":17,"title":["Factors associated with nonresponse to proton pump inhibitors therapy in patients referred for esophageal pH-impedance monitoring"],"prefix":"10.1093","volume":"29","author":[{"given":"A.","family":"Garros","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon; Digestive Physiology; Edouard Herriot Hospital; Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mion","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon; Digestive Physiology; Edouard Herriot Hospital; Lyon France"},{"name":"Lyon I University; Lyon France"},{"name":"LabTAU; Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Marjoux","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon; Digestive Physiology; Edouard Herriot Hospital; Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Damon","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon; Digestive Physiology; Edouard Herriot Hospital; Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Roman","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon; Digestive Physiology; Edouard Herriot Hospital; Lyon France"},{"name":"Lyon I University; Lyon France"},{"name":"LabTAU; Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"10.1111\/dote.12374-BIB0001|dote12374-cit-0001","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.2004.051821","article-title":"Epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"54","author":"Dent","year":"2005","journal-title":"Gut"},{"key":"10.1111\/dote.12374-BIB0002|dote12374-cit-0002","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","article-title":"The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus","volume":"101","author":"Vakil","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/dote.12374-BIB0003|dote12374-cit-0003","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S1542-3565(04)00288-5","article-title":"Effectiveness of proton pump inhibitors in nonerosive reflux disease","volume":"2","author":"Dean","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/dote.12374-BIB0004|dote12374-cit-0004","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1111\/j.1572-0241.2003.07665.x","article-title":"Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs","volume":"98","author":"Inadomi","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/dote.12374-BIB0005|dote12374-cit-0005","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/gutjnl-2011-301897","article-title":"Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors","volume":"61","author":"Sifrim","year":"2012","journal-title":"Gut"},{"key":"10.1111\/dote.12374-BIB0006|dote12374-cit-0006","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1053\/j.gastro.2004.08.014","article-title":"The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis","volume":"128","author":"Barlow","year":"2005","journal-title":"Gastroenterology"},{"issue":"Suppl. 1","key":"10.1111\/dote.12374-BIB0007|dote12374-cit-0007","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.0953-0673.2004.01835.x","article-title":"Review article: approaches to endoscopic-negative reflux disease: part of the GERD spectrum or a unique acid-related disorder?","volume":"19","author":"Tack","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/dote.12374-BIB0008|dote12374-cit-0008","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/gut.2010.228064","article-title":"BMI is superior to symptoms in predicting response to proton pump inhibitor: randomised trial in patients with upper gastrointestinal symptoms and normal endoscopy","volume":"60","author":"Fletcher","year":"2011","journal-title":"Gut"},{"key":"10.1111\/dote.12374-BIB0009|dote12374-cit-0009","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1111\/j.1572-0241.2008.02033.x","article-title":"Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: \u2018on\u2019 or \u2018off\u2019 proton pump inhibitor?","volume":"103","author":"Hemmink","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/dote.12374-BIB0010|dote12374-cit-0010","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1572-0241.2006.00711.x","article-title":"Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy","volume":"101","author":"Zerbib","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/dote.12374-BIB0011|dote12374-cit-0011","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00535-011-0480-0","article-title":"Impedance-pH reflux patterns can differentiate non-erosive reflux disease from functional heartburn patients","volume":"47","author":"Savarino","year":"2012","journal-title":"J Gastroenterol"},{"key":"10.1111\/dote.12374-BIB0012|dote12374-cit-0012","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1365-2036.2009.04142.x","article-title":"Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care","volume":"30","author":"Jones","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/dote.12374-BIB0013|dote12374-cit-0013","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1111\/dote.12374-BIB0014|dote12374-cit-0014","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"issue":"Suppl. 1","key":"10.1111\/dote.12374-BIB0015|dote12374-cit-0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2982.2011.01834.x","article-title":"Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal esophageal pressure topography (EPT)","volume":"24","author":"Bredenoord","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/dote.12374-BIB0016|dote12374-cit-0016","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2003.033290","article-title":"Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux","volume":"53","author":"Sifrim","year":"2004","journal-title":"Gut"},{"key":"10.1111\/dote.12374-BIB0017|dote12374-cit-0017","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cgh.2012.10.041","article-title":"Normal values of pharyngeal and esophageal 24-hour pH impedance in individuals on and off therapy and interobserver reproducibility","volume":"11","author":"Zerbib","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/dote.12374-BIB0018|dote12374-cit-0018","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/0016-5085(94)90815-X","article-title":"The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data","volume":"107","author":"Weusten","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1111\/dote.12374-BIB0019|dote12374-cit-0019","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1136\/gut.2008.175810","article-title":"Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease","volume":"58","author":"Savarino","year":"2009","journal-title":"Gut"},{"key":"10.1111\/dote.12374-BIB0020|dote12374-cit-0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-2036.2008.03596.x","article-title":"The influence of co-morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastro-oesophageal reflux disease","volume":"27","author":"Nojkov","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1111\/dote.12374-BIB0021|dote12374-cit-0021","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/gutjnl-2011-300798","article-title":"Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease","volume":"61","author":"Zerbib","year":"2012","journal-title":"Gut"},{"key":"10.1111\/dote.12374-BIB0022|dote12374-cit-0022","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/ajg.2014.63","article-title":"Acid-based parameters on pH-impedance testing predict symptom improvement with medical management better than impedance parameters","volume":"109","author":"Patel","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"1 Suppl.","key":"10.1111\/dote.12374-BIB0023|dote12374-cit-0023","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2982.2006.00873.x","article-title":"Peripheral and central mechanisms of visceral sensitization in man","volume":"19","author":"Anand","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/dote.12374-BIB0024|dote12374-cit-0024","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.gie.2008.09.022","article-title":"Esophageal-reflux monitoring","volume":"69","author":"Pandolfino","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"10.1111\/dote.12374-BIB0025|dote12374-cit-0025","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/MCG.0000000000000051","article-title":"pH-Impedance findings and proton pump inhibitors-responsiveness in patients with typical gastroesophageal reflux disease symptoms in a large single-center Italian series","volume":"48","author":"Vailati","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"10.1111\/dote.12374-BIB0026|dote12374-cit-0026","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.dld.2012.01.007","article-title":"Increased frequency and enhanced perception of reflux in non-erosive reflux disease patients non-responders to proton pump inhibitors","volume":"44","author":"Ribolsi","year":"2012","journal-title":"Dig Liver Dis"},{"key":"10.1111\/dote.12374-BIB0027|dote12374-cit-0027","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s00464-011-1646-9","article-title":"Value of preoperative esophageal function studies before laparoscopic antireflux surgery","volume":"25","author":"Chan","year":"2011","journal-title":"Surg Endosc"},{"key":"10.1111\/dote.12374-BIB0028|dote12374-cit-0028","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/bjs.5532","article-title":"Characterization of reflux events after fundoplication using combined impedance-pH recording","volume":"94","author":"Roman","year":"2007","journal-title":"Br J Surg"},{"key":"10.1111\/dote.12374-BIB0029|dote12374-cit-0029","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2036.2012.05106.x","article-title":"Long-term, open-label trial: safety and efficacy of continuous maintenance treatment with pantoprazole for up to 15 years in severe acid-peptic disease","volume":"36","author":"Brunner","year":"2012","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdote.12374","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T07:11:38Z","timestamp":1498201898000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article-lookup\/doi\/10.1111\/dote.12374"}},"subtitle":["Factors of nonresponse to PPI therapy"],"short-title":[],"issued":{"date-parts":[[2015,5,8]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,10]]}},"URL":"https:\/\/doi.org\/10.1111\/dote.12374","archive":["Portico"],"relation":{},"ISSN":["1120-8694"],"issn-type":[{"value":"1120-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5,8]]}}}