{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:34:00Z","timestamp":1776742440428,"version":"3.51.2"},"reference-count":32,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"funder":[{"name":"People's Republic of China"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81072360"],"award-info":[{"award-number":["81072360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Basic and Frontier Research in Henan Province","award":["122300410074"],"award-info":[{"award-number":["122300410074"]}]},{"name":"Excellent Youth Foundation of Henan Scientific Committee","award":["124100510007"],"award-info":[{"award-number":["124100510007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases of the Esophagus"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1111\/dote.12463","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T13:44:19Z","timestamp":1460295859000},"source":"Crossref","is-referenced-by-count":5,"title":["Two novel polymorphisms in<i>PLCE1<\/i>are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population"],"prefix":"10.1093","author":[{"given":"Y.","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health; Zhengzhou University; Zhengzhou China"},{"name":"Key Laboratory of Tumor Epidemiology; Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health; Zhengzhou University; Zhengzhou China"},{"name":"Key Laboratory of Tumor Epidemiology; Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Digestive System; Navy General Hospital; Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health; Zhengzhou University; Zhengzhou China"},{"name":"Key Laboratory of Tumor Epidemiology; Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health; Zhengzhou University; Zhengzhou China"},{"name":"Key Laboratory of Tumor Epidemiology; Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health; Zhengzhou University; Zhengzhou China"},{"name":"Key Laboratory of Tumor Epidemiology; Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health; Zhengzhou University; Zhengzhou China"},{"name":"Key Laboratory of Tumor Epidemiology; Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health; Zhengzhou University; Zhengzhou China"},{"name":"Key Laboratory of Tumor Epidemiology; Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"10.1111\/dote.12463-BIB0001|dote12463-cit-0001","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1111\/dote.12463-BIB0002|dote12463-cit-0002","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1111\/dote.12463-BIB0003|dote12463-cit-0003","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/gutjnl-2014-308124","article-title":"Global incidence of oesophageal cancer by histological subtype in 2012","volume":"64","author":"Arnold","year":"2015","journal-title":"Gut"},{"key":"10.1111\/dote.12463-BIB0004|dote12463-cit-0004","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/01635580701883011","article-title":"Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study","volume":"60","author":"Fan","year":"2008","journal-title":"Nutr Cancer"},{"key":"10.1111\/dote.12463-BIB0005|dote12463-cit-0005","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/ije\/26.6.1159","article-title":"Familial aggregation of oesophageal cancer in a high incidence area in China","volume":"26","author":"Chang-Claude","year":"1997","journal-title":"Int J Epidemiol"},{"key":"10.1111\/dote.12463-BIB0006|dote12463-cit-0006","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ygeno.2007.06.006","article-title":"mtDNA evidence: genetic background associated with related populations at high risk for esophageal cancer between Chaoshan and Taihang Mountain areas in China","volume":"90","author":"Li","year":"2007","journal-title":"Genomics"},{"key":"10.1111\/dote.12463-BIB0007|dote12463-cit-0007","first-page":"tr3","article-title":"The inositol trisphosphate (IP3) signal transduction pathway","volume":"3","author":"Thatcher","year":"2010","journal-title":"Sci Signal"},{"key":"10.1111\/dote.12463-BIB0008|dote12463-cit-0008","doi-asserted-by":"crossref","first-page":"e31932","DOI":"10.1371\/journal.pone.0031932","article-title":"Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population","volume":"7","author":"Wang","year":"2012","journal-title":"PloS One"},{"key":"10.1111\/dote.12463-BIB0009|dote12463-cit-0009","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1245\/s10434-011-2160-y","article-title":"Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations","volume":"19","author":"Hu","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1111\/dote.12463-BIB0010|dote12463-cit-0010","doi-asserted-by":"crossref","first-page":"8808","DOI":"10.1158\/0008-5472.CAN-04-3143","article-title":"Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development","volume":"64","author":"Bai","year":"2004","journal-title":"Cancer Res"},{"key":"10.1111\/dote.12463-BIB0011|dote12463-cit-0011","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cancergencyto.2010.01.021","article-title":"RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line","volume":"200","author":"Ou","year":"2010","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1111\/dote.12463-BIB0012|dote12463-cit-0012","first-page":"2039","article-title":"Screening of new tumor suppressor genes in sporadic colorectal cancer patients","volume":"55","author":"Wang","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"10.1111\/dote.12463-BIB0013|dote12463-cit-0013","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ng.648","article-title":"Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20 or f54","volume":"42","author":"Wang","year":"2010","journal-title":"Nat Genet"},{"key":"10.1111\/dote.12463-BIB0014|dote12463-cit-0014","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/ng.2411","article-title":"Genome-wide association studies of gastric adenocarcinoma and esophageal squamous cell carcinoma identify a shared susceptibility locus in PLCE1 at","volume":"44","author":"Abnet","year":"2012","journal-title":"Nat Genet"},{"key":"10.1111\/dote.12463-BIB0015|dote12463-cit-0015","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ng.849","article-title":"Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations","volume":"43","author":"Wu","year":"2011","journal-title":"Nat Genet"},{"key":"10.1111\/dote.12463-BIB0016|dote12463-cit-0016","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.gene.2013.08.057","article-title":"Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population","volume":"530","author":"Cui","year":"2013","journal-title":"Gene"},{"key":"10.1111\/dote.12463-BIB0017|dote12463-cit-0017","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.canep.2013.04.009","article-title":"Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: based on published genome-wide association studies in a central Chinese population","volume":"37","author":"Duan","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"10.1111\/dote.12463-BIB0018|dote12463-cit-0018","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.1007\/s11033-012-1782-x","article-title":"Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population","volume":"39","author":"Gu","year":"2012","journal-title":"Mol Biol Rep"},{"key":"10.1111\/dote.12463-BIB0019|dote12463-cit-0019","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/carcin\/bgr051","article-title":"Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population","volume":"32","author":"Zhang","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1111\/dote.12463-BIB0020|dote12463-cit-0020","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1471-2407-11-258","article-title":"Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck","volume":"11","author":"Ma","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1111\/dote.12463-BIB0021|dote12463-cit-0021","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1007\/s13277-013-0932-7","article-title":"PLCE1 rs2274223 A > G polymorphism and cancer risk: a meta-analysis","volume":"34","author":"Umar","year":"2013","journal-title":"Tumor Biol"},{"key":"10.1111\/dote.12463-BIB0022|dote12463-cit-0022","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1007\/s11033-012-1820-8","article-title":"Association of 10q23 with colorectal cancer in a Chinese population","volume":"39","author":"Li","year":"2012","journal-title":"Mol Biol Rep"},{"key":"10.1111\/dote.12463-BIB0023|dote12463-cit-0023","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.7314\/APJCP.2012.13.6.2519","article-title":"Association of genetic polymorphisms at 1q22 but not 10q23 with gastric cancer in a southern Chinese population","volume":"13","author":"Yang","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1111\/dote.12463-BIB0024|dote12463-cit-0024","first-page":"795","article-title":"Relationship between rs2274223 and rs3765524 polymorphisms of PLCE1 and risk of esophageal squamous cell carcinoma in a Kazakh Chinese population","volume":"42","author":"Chen","year":"2013","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"10.1111\/dote.12463-BIB0025|dote12463-cit-0025","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00439-013-1276-5","article-title":"Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population","volume":"132","author":"Gao","year":"2013","journal-title":"Hum Genet"},{"key":"10.1111\/dote.12463-BIB0026|dote12463-cit-0026","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/1471-2407-9-269","article-title":"Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China","volume":"9","author":"Gao","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1111\/dote.12463-BIB0027|dote12463-cit-0027","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1038\/bjc.2014.172","article-title":"Dietary patterns and oesophageal squamous cell carcinoma: a systematic review and meta-analysis","volume":"110","author":"Liu","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1111\/dote.12463-BIB0028|dote12463-cit-0028","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ajg.2014.71","article-title":"The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis","volume":"109","author":"Prabhu","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/dote.12463-BIB0029|dote12463-cit-0029","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.tig.2004.09.007","article-title":"Genetics, statistics and human disease: analytical retooling for complexity","volume":"20","author":"Thornton-Wells","year":"2004","journal-title":"Trends Genet"},{"key":"10.1111\/dote.12463-BIB0030|dote12463-cit-0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000073735","article-title":"The ubiquitous nature of epistasis in determining susceptibility to common human diseases","volume":"56","author":"Moore","year":"2003","journal-title":"Hum Hered"},{"key":"10.1111\/dote.12463-BIB0031|dote12463-cit-0031","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000081252","article-title":"Dynamic relationships between the genome and exposures to environments as causes of common human diseases","volume":"93","author":"Sing","year":"2004","journal-title":"World Rev Nutr Diet"},{"key":"10.1111\/dote.12463-BIB0032|dote12463-cit-0032","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrg1578","article-title":"Gene-environment interactions in human diseases","volume":"6","author":"Hunter","year":"2005","journal-title":"Nat Rev Genet"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdote.12463","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/dote\/article-pdf\/30\/1\/1\/9600296\/dote12463.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T22:00:24Z","timestamp":1503612024000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article-lookup\/doi\/10.1111\/dote.12463"}},"subtitle":["<i>PLCE1<\/i>polymorphisms and esophageal squamous cell carcinoma risk"],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":32,"URL":"https:\/\/doi.org\/10.1111\/dote.12463","archive":["Portico"],"relation":{},"ISSN":["1120-8694"],"issn-type":[{"value":"1120-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}