{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:23Z","timestamp":1787014103275,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1111\/dth.12457","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T04:48:20Z","timestamp":1484714900000},"page":"e12457","source":"Crossref","is-referenced-by-count":26,"title":["Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: A meta-analysis and systematic review"],"prefix":"10.1155","volume":"30","author":[{"given":"Xiaowei","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Dermatovenerology; Affiliated Hospital of North Sichuan Medical College; Nanchong Sichuan Province 637000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincai","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Dermatovenerology; Affiliated Hospital of North Sichuan Medical College; Nanchong Sichuan Province 637000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Ran","sequence":"additional","affiliation":[{"name":"Departments of Dermatovenerology; West China Hospital, Sichuan University; Chengdu Sichuan Province 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"10.1111\/dth.12457-BIB0001|dth12457-cit-0002","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/bjd.13358","article-title":"British Association of Dermatologists' guidelines for the management of onychomycosis 2014","volume":"171","author":"Ameen","year":"2014","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0002|dth12457-cit-0003","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/bjd.13934","article-title":"Efficacy of topical resin lacquer, amorolfine, and oral terbinafine for treating toenail onychomycosis: a prospective, randomized, controlled, investigator-blinded, parallel-group clinical trial","volume":"173","author":"Auvinen","year":"2015","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0003|dth12457-cit-0004","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1046\/j.1365-2133.2000.03545.x","article-title":"A randomized trial of amorolfine 5% solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix region","volume":"142","author":"Baran","year":"2000","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0004|dth12457-cit-0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2133.2007.07974.x","article-title":"A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement","volume":"157","author":"Baran","year":"2007","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0005|dth12457-cit-0006","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/clinids\/2.4.520","article-title":"Mechanism of action of antifungals with special reference to the imidazole derivatives","volume":"2","author":"Borgers","year":"1980","journal-title":"Review of Infectious Diseases"},{"key":"10.1111\/dth.12457-BIB0006|dth12457-cit-0007","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/09546634.2015.1109029","article-title":"Efficacy of 5% amorolfine nail lacquer in Neoscytalidium dimidiatum onychomycosis","volume":"27","author":"Bunyaratavej","year":"2016","journal-title":"Journal of Dermatological Treatment"},{"key":"10.1111\/dth.12457-BIB0007|dth12457-cit-0008","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/jpc.12740","article-title":"Case of infantile onychomycosis successfully cured by 5% amorolfine nail lacquer","volume":"50","author":"Chen","year":"2014","journal-title":"Journal of Pediatrics and Child Health"},{"key":"10.1111\/dth.12457-BIB0008|dth12457-cit-0009","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/CMR.11.3.415","article-title":"Onychomycosis: pathogenesis, diagnosis and management","volume":"11","author":"Elewski","year":"1998","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1111\/dth.12457-BIB0009|dth12457-cit-0010","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/1346-8138.12577","article-title":"Efficacy and tolerability of luliconazole cream 1% for dermatophytoses: a meta-analysis","volume":"41","author":"Feng","year":"2014","journal-title":"Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0010|dth12457-cit-0011","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2133.1992.tb00006.x","article-title":"Pharmacokinetics of terbinafine in the nail","volume":"126","author":"Finlay","year":"1992","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0011|dth12457-cit-0012","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/AAC.04842-14","article-title":"Ability of hydroxypropyl chitosan naillacquer to protect against dermatophyte nail infection","volume":"59","author":"Ghannoum","year":"2015","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1111\/dth.12457-BIB0012|dth12457-cit-0013","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/bjd.12594","article-title":"A second look at efficacy criteria for onychomycosis: clinical and mycological cure","volume":"170","author":"Ghannoum","year":"2014","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0013|dth12457-cit-0014","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s13555-016-0093-x","article-title":"Amorolfine 5% nail lacquer exhibits potent antifungal activity compared to three acid-based devices indicated for the treatment of onychomycosis: an in vitro\u00a0nail penetration assay","volume":"6","author":"Ghannoum","year":"2016","journal-title":"Dermatology and Therapy (Heidelberg)"},{"key":"10.1111\/dth.12457-BIB0014|dth12457-cit-0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1365-4362.2000.00964.x","article-title":"An evaluation of intermittent therapies used to treat onychomycosis and other dermatomycoses with the oral antifungal agents","volume":"39","author":"Gupta","year":"2000","journal-title":"International Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0015|dth12457-cit-0016","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s40257-014-0096-2","article-title":"Topical therapy for toenail onychomycosis: an evidence-based review","volume":"15","author":"Gupta","year":"2014","journal-title":"American Journal of Clinical Dermatology"},{"key":"10.1111\/dth.12457-BIB0016|dth12457-cit-0017","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000433473","article-title":"Network meta-analysis of onychomycosis treatments","volume":"1","author":"Gupta","year":"2015","journal-title":"Skin Appendage Disorders"},{"key":"10.1111\/dth.12457-BIB0017|dth12457-cit-0018","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000441569","article-title":"Ciclopirox 8% hpch nail lacquer in the treatment of mild-to-moderate onychomycosis: a randomized, double-blind amorolfine controlled study using a blinded evaluator","volume":"1","author":"Iorizzo","year":"2016","journal-title":"Skin Appendage Disord"},{"key":"10.1111\/dth.12457-BIB0018|dth12457-cit-0019","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4103\/0378-6323.37056","article-title":"An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis","volume":"73","author":"Jaiswal","year":"2007","journal-title":"Indian Journal of Dermatology, Venereology, and Leprology"},{"key":"10.1111\/dth.12457-BIB0020|dth12457-cit-0021","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2133.2001.145s60021.x","article-title":"Amorolfine and itraconazole combination for severe toenail onychomycosis; results of an open randomized trial in Spain","volume":"145","author":"Lecha","year":"2001","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0021|dth12457-cit-0022","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0011-393X(02)80040-6","article-title":"An open-label, multicenter study of the combination of amorolfine nail lacquer and oral ltraconazole compared with oral ltraconazole alone in the treatment of severe toenail onychomycosis","volume":"63","author":"Lecha","year":"2002","journal-title":"Current Therapeutic Research - Clinical and Experimental"},{"key":"10.1111\/dth.12457-BIB0022|dth12457-cit-0023","doi-asserted-by":"crossref","DOI":"10.4159\/9780674040243","volume-title":"Summing up: the science of reviewing research","author":"Light","year":"1984"},{"key":"10.1111\/dth.12457-BIB0023|dth12457-cit-0024","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/S0190-9622(08)81272-8","article-title":"Mycology of nail disorders","volume":"31","author":"Midgley","year":"1994","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.1111\/dth.12457-BIB0024|dth12457-cit-0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2165\/00003495-199958020-00005","article-title":"Management of onychomycoses","volume":"58","author":"Niewerth","year":"1999","journal-title":"Drugs"},{"key":"10.1111\/dth.12457-BIB0025|dth12457-cit-0026","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2133.2003.05381.x","article-title":"A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis","volume":"149","author":"Rigopoulos","year":"2003","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0026|dth12457-cit-0027","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2133.1994.tb06087.x","article-title":"Onychomycosis is more than a cosmetic problem","volume":"130","author":"Scher","year":"1994","journal-title":"British Journal of Dermatology"},{"key":"10.1111\/dth.12457-BIB0027|dth12457-cit-0028","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jaad.2006.12.019","article-title":"Onychomycosis: diagnosis and definition of cure","volume":"56","author":"Scher","year":"2007","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.1111\/dth.12457-BIB0028|dth12457-cit-0029","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/myc.12369","article-title":"Sporicidal effect of amorolfine and other antimycotics used in the therapy of fungal nail infections","volume":"58","author":"Seidl","year":"2015","journal-title":"Mycoses"},{"key":"10.1111\/dth.12457-BIB0029|dth12457-cit-0030","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/myc.12473","article-title":"Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal ubungual toenail onychomycosis: results of a randomized active-controlled study and in vitro assays","volume":"59","author":"Sigurgeirsson","year":"2016","journal-title":"Mycoses"},{"key":"10.1111\/dth.12457-BIB0030|dth12457-cit-0031","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1468-3083.2009.03547.x","article-title":"Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years","volume":"24","author":"Sigurgeirsson","year":"2010","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"10.1111\/dth.12457-BIB0031|dth12457-cit-0032","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5114\/pdia.2014.40968","article-title":"Amorolfine vs. ciclopirox - lacquers for the treatment of onychomycosis","volume":"32","author":"Tabara","year":"2015","journal-title":"Postepy Dermatologii i Alergologii"},{"key":"10.1111\/dth.12457-BIB0032|dth12457-cit-0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1348-0421.12109","article-title":"In vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes","volume":"58","author":"Tamura","year":"2014","journal-title":"Microbiology and Immunology"},{"key":"10.1111\/dth.12457-BIB0033|dth12457-cit-0034","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00002512-200421020-00003","article-title":"Common fungal infections of the feet in patients with diabetes mellitus","volume":"21","author":"Tan","year":"2004","journal-title":"Drugs & Aging"},{"key":"10.1111\/dth.12457-BIB0019|dth12457-cit-0020","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s10103-016-1990-z","article-title":"Combination therapy for onychomycosis using a fractional 2940-nm Er:YAG laser and 5% amorolfine lacquer","volume":"31","author":"Zhang","year":"2016","journal-title":"Lasers in Medical Science"},{"key":"10.1111\/dth.12457-BIB0034|dth12457-cit-0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2230.1992.tb00281.x","article-title":"Amorolfine in the treatment of onychomycosis and dermatomycoses-an overview","volume":"17","author":"Zuag","year":"1992","journal-title":"Clinical and Experimental Dermatology"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdth.12457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/dth.12457\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T12:56:35Z","timestamp":1671800195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.12457"}},"subtitle":["Feng et al."],"short-title":[],"issued":{"date-parts":[[2017,1,18]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"URL":"https:\/\/doi.org\/10.1111\/dth.12457","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,18]]}}}