{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:13:49Z","timestamp":1773400429062,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20180201KJ"],"award-info":[{"award-number":["JJKH20180201KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sporotrichosis is a fungal disease of the human and other mammals, caused by a complex of\n                    <jats:italic>Sporothrix schenckii<\/jats:italic>\n                    . The disease follows the traumatic inoculation to lead to fixed lesions, regional lymphangitic lesions, or even disseminated lesions including internal involvement, which depends on host immunological status and strain virulence. In this work, we observed the role of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells apoptosis and conversion of Th1\/Th2\u2010type cytokines in the cellular immunity regulation on mice model sporotrichosis. The experiments showed that there was more CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells apoptosis, by endogenous apoptosis signaling pathway (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05), and more conversions of Th1\/Th2\u2010type cytokines in more severe and longer duration groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Meanwhile, the trends of the conversions of Th1\/Th2\u2010type cytokines were almost consistent with the CD4\u2009+\u2009T cell's apoptosis in the corresponding groups. These findings suggest that CD4+ T cells apoptosis and conversion of Th1\/Th2\u2010type cytokines are contributing to promoting the progress of sporotrichosis.\n                  <\/jats:p>","DOI":"10.1111\/dth.14720","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T17:11:30Z","timestamp":1609175490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CD4\n                    <sup>+<\/sup>\n                    T cells apoptosis and conversion of Th1\/Th2\u2010type cytokines promote the progress of sporotrichosis"],"prefix":"10.1155","volume":"34","author":[{"given":"Yong\u2010Zhi","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang\u2010Lin","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Pathology The Second Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Li","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Dermatology FAW General Hospital  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-1199","authenticated-orcid":false,"given":"Shi\u2010Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2010.0127"},{"issue":"15","key":"e_1_2_8_3_1","first-page":"1257","article-title":"Effect of glaucocalyxin a on level of Th1\/Th2 type cytokines in mice","volume":"31","author":"Chen 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cytokines gene in human gliomas","volume":"20","author":"Li G","year":"2005","journal-title":"Chin Med Sci J"},{"issue":"8","key":"e_1_2_8_10_1","first-page":"606","article-title":"Study on the correlation of the effect of entecavir on Th1\/Th2 cytokines level in the treatment of chronic hepatitis","volume":"25","author":"Li L","year":"2017","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880803100405"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.53143"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2005.01673.x"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"11","article-title":"HLA\u2010DRBeta1, circulating Th1\/Th2 cytokines and immunological homunculus in coronary atherosclerosis","volume":"10","author":"Mostafazadeh A","year":"2011","journal-title":"Iran J Allergy Asthma 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