{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:23:51Z","timestamp":1789759431125,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surgical methods are favorably used for treatment of stable vitiligo, and platelet\u2010rich plasma (PRP) can be added to augment the effect. The additive value of PRP, however, remains elusive. Basic fibroblast growth factor (bFGF) is released from activated platelets with a capacity for stimulating melanocyte proliferation and migration. The treatment outcomes for the mini\u2010punch grafting (MPG)\/phototherapy treatment with and without PRP were assessed and the relation between bFGF and the obtained results were evaluated. Thirty\u2010four vitiliginous patches, two per each patient with stable vitiligo, were enrolled in this intrapatient\u2010controlled study and treated with autologous MPG and subsequent exposure to phototherapy with and without enhancement via PRP procedure at the time of the procedure, and monthly for the subsequent 3 months. Re\u2010pigmentation assessment via vitiligo scores as well as measurement of lesional bFGF were done. PRP assistance to MPG\/phototherapy treatment resulted in earlier re\u2010pigmentation at week 8. However, this enhancement effect vanished at the study end (week 20) as ideal re\u2010pigmentation (&gt;75% re\u2010pigmentation) was encountered in 10 patches (58.8%) treated with MPG\/phototherapy modality, and in 12 patches (70.6%) treated with PRP\u2010assisted method without significant difference between them. Lesional bFGF increased after both treatments with a higher expression with PRP assistance but without clinical reflection on the final outcome. PRP can speed the re\u2010pigmentation response for MPG\/phototherapy procedure without any significant effect on the final outcome.<\/jats:p>","DOI":"10.1111\/dth.14738","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T17:54:56Z","timestamp":1609955696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of platelet\u2010rich plasma on the outcome of mini\u2010punch grafting procedure in localized stable vitiligo: Clinical evaluation and relation to lesional basic fibroblast growth factor"],"prefix":"10.1155","volume":"34","author":[{"given":"Samar Abdallah M.","family":"Salem","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabarek Abdulkhaleq","family":"Fezeaa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-4674","authenticated-orcid":false,"given":"Nashwa","family":"El Khazragy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology\u2010Hematology and Ain Shams Medical Research Institute (MASRI), Faculty of Medicine Ain\u2010Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-7763","authenticated-orcid":false,"given":"Marwa Y.","family":"Soltan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0298-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.53195"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.150734"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S239912"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.4.1611"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0161"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1531"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000407130.56575.30"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12397"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S178817"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14286"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001641"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08881.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.4.407"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12730"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12426"},{"issue":"6","key":"e_1_2_7_18_1","first-page":"1183","article-title":"Expression of bFGF and TGF\u2010beta 2 in experimental myopia in chicks","volume":"36","author":"Seko Y","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14356"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12194"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13103"},{"key":"e_1_2_7_22_1","unstructured":"LimHK ShinMK LeeMH.Clinical application of PRP in vitiligo: a pilot study. In: International Pigment Cell Conference IPCC;2011."}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.14738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:57:37Z","timestamp":1764169057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.14738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/dth.14738"],"URL":"https:\/\/doi.org\/10.1111\/dth.14738","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,13]]},"assertion":[{"value":"2020-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14738"}}