{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:10:41Z","timestamp":1790993441793,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polypodium leucotomos displayed a synergic effect with NB\u2010UVB in psoriasis, but its application on vitiligo remains understudied. The aim of this study was to investigate whether oral supplementation with leaves extract of Polypodium leucotomos (PL) improves narrow band (NB) UVB phototherapy\u2010induced repigmentation. Forty\u2010four patients with generalized vitiligo were enrolled in this randomized, prospective, placebo controlled study. Twenty\u2010three patients were randomly selected to receive combined treatment with NB\u2010UVB phototherapy and 480\u2009mg oral PL twice daily while 21 patients received NB\u2010UVB phototherapy combined with placebo. All subjects were treated with NB\u2010UVB twice weekly for 6 months. Our results demonstrated that oral PL combined with NB\u2010UVB improved repigmentation as well as increased the response rate compared with patients treated with NB\u2010UVB alone (47.8% vs 22%). Our study suggests that oral supplementation of PL and NB\u2010UVB phototherapy enhance the extent of repigmentation.<\/jats:p>","DOI":"10.1111\/dth.14776","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T02:48:16Z","timestamp":1610678896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["NB\u2010UVB plus oral Polypodium leucotomos extract display higher efficacy than NB\u2010UVB alone in patients with vitiligo"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-0620","authenticated-orcid":false,"given":"Alessia","family":"Pacifico","sequence":"first","affiliation":[{"name":"Clinical Dermatology Department S. Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2390-6505","authenticated-orcid":false,"given":"Giovanni","family":"Damiani","sequence":"additional","affiliation":[{"name":"Clinical Dermatology IRCCS Istituto Ortopedico Galeazzi  Milan Italy"},{"name":"Department of Biomedical Surgical and Dental Sciences University of Milan  Milan Italy"},{"name":"PhD Degree Program in Pharmacological Sciences, Department of Pharmaceutical and Pharmacological Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Iacovelli","sequence":"additional","affiliation":[{"name":"Clinical Dermatology Department S. Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalynn R.Z.","family":"Conic","sequence":"additional","affiliation":[{"name":"Department of Dermatology Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Young Dermatologists Italian Network (YDIN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties Alcal\u00e0 University and Ramon y Cajal Hospital, Ctra, De Colmenar Viejo  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Morrone","sequence":"additional","affiliation":[{"name":"Clinical Dermatology Department S. Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00333.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.11"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061592"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.12.1582"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.126"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02514.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/b9pp00156e"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.12.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02132.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2003101p73"},{"key":"e_1_2_9_14_1","first-page":"148","article-title":"Role of oral Polypodium leucotomos extract in dermatologic disease: a review of the literature","volume":"13","author":"Choudhry SZ","year":"2014","journal-title":"J Drugs Dermatol"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.14776","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:59:36Z","timestamp":1764169176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.14776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/dth.14776"],"URL":"https:\/\/doi.org\/10.1111\/dth.14776","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,5]]},"assertion":[{"value":"2020-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14776"}}