{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:05:14Z","timestamp":1764169514759,"version":"3.46.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00708","PI18\/00858"],"award-info":[{"award-number":["PI18\/00708","PI18\/00858"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Photodynamic therapy (PDT) is an established nonsurgical treatment for nodular basal cell carcinoma (nBCC). This study compares the clinical, histopathological, and immunohistochemical findings in recurrent nBCC after PDT versus pre\u2010treatment (primary) nBCC. This retrospective study analyzed nodular BCCs treated with methyl aminolevulinate (MAL)\u2010PDT at the Department of Dermatology, San Jorge Hospital (Huesca, Spain), between 2006 and 2015. Only cases in which both the primary and the recurring tumor were histologically confirmed were included in the analysis. Data on clinical, histological, and immunohistochemical variables were collected. The analysis included a total of 15 nBCCs resistant to 2 sessions of MAL\u2010PDT: 11 (73.3%) were persistent BCCs (cure not achieved within 3 months of treatment) and 4 (26.7%) recurred in the first 2\u2009years of follow\u2010up. Subsequent biopsies of the 11 persistent nBCCs revealed that 9 (81.8%) retained the same histological type while the other 2 (18.2%) had another histological variant (micronodular and metatypical). Biopsy of the 4 recurring nBCCs revealed a persistent nodular subtype in all cases. MAL\u2010PDT resulted in no changes in p53, survivin or \u03b2\u2010catenin expression, and trend toward increased EGFR immunostaining. Histology revealed a trend toward a dense stroma without ulceration in recurrent nBCC after PDT. Trend toward increased EGFR immunostaining, and no changes in survivin (which remained negative or mildly positive) or \u03b2\u2010catenin, (which remained moderately or our findings indicate that MAL\u2010PDT does not induce histological or immunohistochemical changes that increase tumor aggressiveness.<\/jats:p>","DOI":"10.1111\/dth.14779","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:17:19Z","timestamp":1610695039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative histological and immunohistochemical changes in recurrent nodular basal cell carcinoma after photodynamic therapy"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-2076","authenticated-orcid":false,"given":"Tamara","family":"Gracia\u2010Caza\u00f1a","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital de Barbastro  Huesca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimena","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Departament of Biology Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina Andrea","family":"Cerro\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Dermatology Service Hospital Miguel Servet  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universidad de Alcal\u00e1, Alcal\u00e1 de Henares  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"Juarranz","sequence":"additional","affiliation":[{"name":"Departament of Biology Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Gilaberte","sequence":"additional","affiliation":[{"name":"Dermatology Service Hospital Miguel Servet  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1159\/000339335"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1111\/jdv.13715"},{"unstructured":"Bernabo J Lopez Navarro N Dominguez G Zmudzinska M Herrera\u2010Ceballos E. Histological study of basal cell carcinomas recurring after photodynamic therapy: a comparative analysis against its primary tumors [abstract]. Present 33rd Nord Congr Dermatology Venereol April 27\u201029 Trondheim Norway. s. f.","key":"e_1_2_8_4_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1111\/j.1365-2133.2008.08666.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1038\/jid.2014.178"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1111\/j.1524-4725.2006.32110.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/S0190-9622(99)70409-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1016\/j.jid.2016.03.043"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1111\/j.1468-3083.2012.04628.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1016\/j.jaad.2018.12.028"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1016\/j.adengl.2013.09.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1371\/journal.pone.0215537"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1158\/0008-5472.CAN-06-4785"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1111\/j.1600-0560.2007.00935.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1016\/j.pdpdt.2017.12.015"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.14779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:58:50Z","timestamp":1764169130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.14779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/dth.14779"],"URL":"https:\/\/doi.org\/10.1111\/dth.14779","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"type":"print","value":"1396-0296"}],"subject":[],"published":{"date-parts":[[2021,1,26]]},"assertion":[{"value":"2020-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14779"}}