{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:01:12Z","timestamp":1788451272912,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Androgenetic alopecia (AGA) with its precursor miniaturization of anagen phase (MA) and telogen effluvium (TE) represent nonscarring hair loss diseases which causes moderate to severe aesthetic and psychologic discomfort in affected people. Several therapeutic approaches have been tested through the latest decades, with different degree of success. In this study we aim to analyze the efficacy and outcome of an innovative therapeutic protocol, named TRICHOBIOLIGHT, a combination of active principles conveyed by mesotherapy directly on the scalp with a subsequent photobiostimulation session with LED light (630\u2009nm). About 107 patients (49 women, 58 men, mean age 45\u2010year\u2010old) with clinical and trichoscopic diagnosis of MA, AGA, and TE have been enrolled at Skin Center of L'Aquila, Avezzano and Pescara (Italy) and subsequently treated with the TRICHOBIOLIGHT protocol. 4 patients dropped out at the beginning of the study: 2 patients because of an histological diagnosis of scarring alopecia and lichen scleroatrophicus, and 2 patients dropped out because of adverse reaction to the treatment. Excellent to good outcome have been reached in the 82.5% of patients (85\/103), 9 patients (8.7%) reached a sufficient result while 7 patients (6.8%) partially respond to the treatment. Two patients (2%) did not respond at all. TRICHOBIOLIGHT is a promising protocol, working through the combined action of the active principles and the photobiostimulation, that lead to a strengthening and thickening of the residual hair, giving an optical thickening effect that provides high quality aesthetic results and, consequently, appreciable psychological results.<\/jats:p>","DOI":"10.1111\/dth.14799","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T12:34:11Z","timestamp":1611491651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trichobiolight: A new, effective protocol in the treatment of androgenetic alopecia and telogen effluvium"],"prefix":"10.1155","volume":"34","author":[{"given":"Domenico","family":"Piccolo","sequence":"first","affiliation":[{"name":"Skin Center Avezzano  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-1573","authenticated-orcid":false,"given":"Giuliana","family":"Crisman","sequence":"additional","affiliation":[{"name":"Skin Center Avezzano  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-8873","authenticated-orcid":false,"given":"Claudio","family":"Conforti","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Maggiore Hospital of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Buzzi","sequence":"additional","affiliation":[{"name":"Skin Center Avezzano  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Genovesi","sequence":"additional","affiliation":[{"name":"Skin Center Avezzano  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Marchi","sequence":"additional","affiliation":[{"name":"Skin Center Avezzano  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilla","family":"Mazzaracchio","sequence":"additional","affiliation":[{"name":"Skin Center Avezzano  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000432183.50644.f6"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"15","article-title":"Androgenetic alopecia","volume":"149","author":"Piraccini BM","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.116730"},{"key":"e_1_2_9_5_1","unstructured":"ZhangY.Study of the differences on hair follicle between AGA and healthy [PhD thesis]. Shanghai China: Second Military Medical University;2016."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-019-01245-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2017.05.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_125_18"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2005.23.3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04535.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.7241\/ourd.20131.08"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"102","article-title":"The use of minoxidil in the treatment of male and female androgenetic alopecia: a story of more than 30\u2009years","volume":"153","author":"Barbareschi M","year":"2018","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_89_18"},{"key":"e_1_2_9_14_1","first-page":"137","article-title":"Mesotherapy using dutasteride\u2010containing solution in male pattern hair loss: a controlled pilot study","volume":"20","author":"Abdallah MA","year":"2009","journal-title":"J Pan Arab Leag Dermatol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X15666200204123722"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb15179.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.03.031"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000155644"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/1110-2098.149746"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01896.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01640.x"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.14799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:57:23Z","timestamp":1764169043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.14799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,7]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/dth.14799"],"URL":"https:\/\/doi.org\/10.1111\/dth.14799","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,7]]},"assertion":[{"value":"2020-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14799"}}