{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:42:16Z","timestamp":1785552136196,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study presents a single center experience with livedoid vasculopathy (LV). A rare disease that can lead to severe quality of life impairment. Characterize clinical data of LV patients at the Dermatology Division at the University of S\u00e3o Paulo. A retrospective and transversal study was conducted, from 1 January 2005 to 31 December 2019. About 75 patients diagnosed as LV and confirmed by skin biopsy were included. Epidemiology, clinical appearance, histopathology data, and treatment history were observed. There were 78.66% Caucasian women, with a mean age of 39.9\u2009years. Frequent cutaneous manifestations were ulcers, atrophic blanche\u2010like scars, hyperpigmentation, purpuras, telangiectasias, and livedo racemosa. Pain, pruritus, and hypoesthesia were the main symptoms. After treatment, almost 40% of cases relapsed during spring and summer months. About 66% of cases had thrombophilia factors associated, such as high levels of lipoprotein(a). Frequent treatments included acetylsalicylic acid, pentoxifylline, and diosmin with hesperidin. Not being a prospective study. This research provides useful data on Latin American LV patients, indicating multifactorial conditions involved in LV pathogenesis. An extensive work\u2010up including autoimmune laboratory tests, thrombophilia factors, and other conditions associated with venous stasis should be part of LV investigation and controlled to improve treatment response.<\/jats:p>","DOI":"10.1111\/dth.14810","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T09:31:19Z","timestamp":1611653479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Livedoid vasculopathy in 75 Brazilian patients in a single\u2010center institution: Clinical, histopathological and therapy evaluation"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-6099","authenticated-orcid":false,"given":"Paulo Ricardo","family":"Criado","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Dermatology Centro Universit\u00e1rio Sa\u00fade ABC  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-6917","authenticated-orcid":false,"given":"Carla","family":"Pagliari","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e2mara Cristiane Alves Batista","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Franco","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Prota Hussein","family":"Pincelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neusa Yuriko Sakai","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Salom\u00e9 Cajas","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-0844","authenticated-orcid":false,"given":"Joz\u00e9lio Freire","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Centro M\u00e9dico do Hospital Alian\u00e7a  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4586-1915","authenticated-orcid":false,"given":"Beatrice Martinez Zugaib","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centro Universit\u00e1rio Sa\u00fade ABC  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian Nacagami","family":"Sotto","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo 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