{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:24Z","timestamp":1787014104460,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Generalized pustular psoriasis (GPP) is a rare, potentially life\u2010threatening inflammatory skin disease. Our aim was to assess patient and disease characteristics and analyze drug survival rates in the treatment of GPP in a real\u2010life setting. In this retrospective study, 201 treatment series of 86 patients with GPP treated at five University Medical Centers were analyzed. Overall, excellent response was reached in 41.3% of all treatment courses, partial response in 31.4%, and nonresponse in 27.3%. Biological treatment was significantly more effective than non\u2010biological therapies (excellent response: 47.4% vs 35.9%;\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.02). Overall, the median drug survival was 14.0 months (biologicals: 36.0 months vs nonbiologicals: 6.0 months;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.001). The crude probability of survival was highest for secukinumab (hazard ratio [HR] of drug discontinuation compared with acitretin: 0.22), followed by ixekizumab and ustekinumab (HR: 0.38 each), adalimumab (HR: 0.59), etanercept (HR: 0.62), infliximab (HR: 0.69), cyclosporine (HR: 1.00), acitretin (reference for HR), fumaric acid esters (HR: 1.06), methotrexate (HR: 1.26), and apremilast (HR: 3.44); no drug discontinuation with guselkumab. Our results reveal high efficacy and drug survival, particularly for IL\u201017 and IL\u2010(12)\/23 antagonists. Thus, these biologics may be considered early in the therapeutic algorithm of GPP.\n                  <\/jats:p>","DOI":"10.1111\/dth.14814","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T13:11:43Z","timestamp":1611666703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Drug survival in the treatment of generalized pustular psoriasis: A retrospective multicenter study"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-4907","authenticated-orcid":false,"given":"Christian","family":"Kromer","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology University Medical Center  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Loewe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sietske","family":"Poortinga","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-7647","authenticated-orcid":false,"given":"Rotraut","family":"Moessner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology University Medical Center  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wilsmann\u2010Theis","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Bonn  Bonn 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