{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:42:34Z","timestamp":1785436954143,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigated the mechanism and efficacy of topical acidified aliphatic ester for treatment of axillary osmidrosis (AO). A total of 32 AO patients were enrolled in this study. In the initial pilot study, 20 patients were double\u2010blindly, randomly divided into acidified aliphatic ester or aliphatic ester treatment groups, followed by efficacy evaluation after 4\u2009weeks. Then, all patients (n = 32) were treated with topical acidified aliphatic ester for 16\u2009weeks. Efficacy was evaluated at every 4\u2009weeks, and at 3\u2010 and 6\u2010month follow\u2010ups. Changes of pH values and microecology at targeting sites were analyzed. In the first cohort (n = 20) of pilot study, acidified aliphatic ester showed significantly higher curative rate (60% vs 10%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.05) and effective rate (90% vs 30%;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.05) than aliphatic ester. For the next 16\u2009weeks, 25 of 32 cases completed treatment. Curative rate showed gradual and significant increases from 64% to 96% during the treatment courses (\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.001); it slightly but insignificantly decreased at 3\u2010 and 6\u2010 month follow\u2010ups. Abundance of\n                    <jats:italic>Corynebacterium and Anaerobic bacteria<\/jats:italic>\n                    decreased while\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    increased after treatments. Axillary pH values negatively correlated with\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    abundance (\n                    <jats:italic>r<\/jats:italic>\n                    =\u2009\u2212.40,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.01) and positively with\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    abundance (\n                    <jats:italic>r<\/jats:italic>\n                    =\u2009.64,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.01). We concluded that topical acidified aliphatic ester could effectively alleviate conditions of AO patients by reducing value of axillary pH and rebalancing axillary microecology.\n                  <\/jats:p>","DOI":"10.1111\/dth.14844","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T08:56:23Z","timestamp":1612515383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of topical acidified aliphatic ester for treatment of axillary osmidrosis by rebalancing skin microecology"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-9586","authenticated-orcid":false,"given":"Jinrong","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Dermatology The Third Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Xiangya Hospital, Central South University  Changsha 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Third Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"4207","article-title":"Microecological investigation and comparison of two clinical methods to evaluate axillary osmidrosis","volume":"22","author":"Du H","year":"2020","journal-title":"Mol Med 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