{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:20:24Z","timestamp":1768879224759,"version":"3.49.0"},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lan et al recently highlighted the under\u2010representation of older adults in clinical trials of systemic therapies for atopic dermatitis (AD). Late\u2010onset AD is increasingly recognized in older adults. Spontaneous remission is uncommon with this phenotype. Existing drug treatments such as corticosteroids, methotrexate, ciclosporin, and azathioprine are complicated by adverse effects including increased malignancy risk, immunosuppression in the context of immunosenescence, and drug interactions in the setting of polypharmacy. A case series is presented of seven patients over 50\u2009years of age with AD who were prescribed dupilumab or tofacitinib or upadacitinib for at least 6\u2009months. All patients were clear or almost clear (investigator global assessment score 0\/1) after 1\u2009month of therapy. No significant adverse events were seen. This case series provides preliminary evidence about the safety and efficacy of these novel drugs for AD in older adults. Further studies with higher numbers of participants are needed to obtain real\u2010world evidence for these drugs in older adults, given the limited data in clinical trials.<\/jats:p>","DOI":"10.1111\/dth.14890","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T23:32:35Z","timestamp":1613604755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel agents for atopic dermatitis in patients over 50\u2009years of age: A case series"],"prefix":"10.1155","volume":"34","author":[{"given":"Lisa","family":"Kiely","sequence":"first","affiliation":[{"name":"Department of Dermatology South Infirmary Victoria University Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Bowe","sequence":"additional","affiliation":[{"name":"Department of Dermatology South Infirmary Victoria University Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-5293","authenticated-orcid":false,"given":"Cathal","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Dermatology South Infirmary Victoria University Hospital  Cork Ireland"},{"name":"Department of Dermatology University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Dermatology South Infirmary Victoria University Hospital  Cork Ireland"},{"name":"Department of Dermatology University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Dermatology South Infirmary Victoria University Hospital  Cork Ireland"},{"name":"Department of Dermatology University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Dermatology South Infirmary Victoria University Hospital  Cork Ireland"},{"name":"Department of Dermatology University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.2940"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12771"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-020-00750-5"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.14890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.14890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:59:37Z","timestamp":1764169177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.14890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/dth.14890"],"URL":"https:\/\/doi.org\/10.1111\/dth.14890","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"2020-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14890"}}