{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:29:00Z","timestamp":1790659740678,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010acne hyperpigmentation is a common undesirable sequela of acne vulgaris that causes distress for many patients. This study's objective was to compare the efficacy of both low\u2010power\/low\u2010density fractional carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser and tranexamic acid (TXA) microinjection on post\u2010acne hyperpigmentation. Twenty\u2010five post\u2010acne hyperpigmentation patients (resistant to regular treatment for more than 6\u2009months) were enrolled in this randomized split\u2010face study. One side of the face was randomly assigned to low\u2010power fractional CO<jats:sub>2<\/jats:sub> laser every 4\u2009weeks, and the other side was assigned to TXA intradermal\u2010microinjection every 2\u2009weeks for 3\u2009months. Efficacy was evaluated using digital photography, dermoscopy, post\u2010acne hyperpigmentation index (PAHPI), melanin index (MI), and erythema index (EI) at baseline and 4\u2009weeks after the last session. Both fractional CO<jats:sub>2<\/jats:sub> laser and TXA microinjection treatment sides showed a significant reduction in the PAHPI and MI (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). There was statistically significant difference with better percentage of improvement regarding total dermoscopic score on the fractional CO<jats:sub>2<\/jats:sub> laser side than the TXA microinjections side (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.009). Both fractional CO<jats:sub>2<\/jats:sub> laser and TXA microinjection are effective and safe treatment options for post\u2010acne hyperpigmentation with potential superiority of fractional CO<jats:sub>2<\/jats:sub> laser. We also believe that dermoscopy could be helpful tool for assessment of pigmentation depth in patients on treatment by analyzing the color pattern.<\/jats:p><jats:p>ClinicalTrials.govID: NCT03765021.<\/jats:p>","DOI":"10.1111\/dth.15103","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T07:37:28Z","timestamp":1629445048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Tranexamic acid versus fractional carbon dioxide laser in post\u2010acne hyperpigmentation"],"prefix":"10.1155","volume":"34","author":[{"given":"Shereen Osama","family":"Tawfic","sequence":"first","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0796","authenticated-orcid":false,"given":"Rania","family":"Abdel Hay","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeel","family":"Salim","sequence":"additional","affiliation":[{"name":"Dermatology specialist Ministry of Health  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-3897","authenticated-orcid":false,"given":"Maha Fathy","family":"Elmasry","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14184"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12050"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0333-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23173"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0263-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12465"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-02023-1_54"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"42","article-title":"Refractory postinflammatory hyperpigmentation treated fractional CO2 laser","volume":"7","author":"Oram 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