{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:45:41Z","timestamp":1757699141848,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary hemorrhagic telangiectasia (HHT) is characterized by telangiectasia and larger arteriovenous malformations (AVM) in different organs. Mucocutaneous telangiectasia can bleed and cause stigmatization, but the best treatment approach has not been defined yet. The aim of the study was to evaluate the efficacy and safety of dual <jats:italic>pulsed dye laser and neodymium: yttrium\u2013aluminum\u2013garnet<\/jats:italic> (PDL\u2010Nd:YAG) laser treatment for mucocutaneous telangiectasia in HHT patients. It is a retrospective case series, where clinical files of all HHT patients treated with PDL\u2010Nd:YAG laser at our Department between December 2010 and July 2019 were reviewed. Demographic, clinical, and treatment characteristics were recorded. The severity and degree of improvement were evaluated by three blinded examiners scoring pretreatment and posttreatment pictures on a 5\u2010point scale. Patient satisfaction and procedure pain were assessed using an ordinal scale (0\u201310). Forty\u2010three treatment areas from 26 patients were analyzed. Lesions were predominantly located on the lower lip and cheeks. The median number of laser sessions per patient was 3 (interquartile range [IQR] 2\u20134). The median global severity score at baseline was 2 and became 0 at endpoint (<jats:italic>p<\/jats:italic> &lt; 0.0001), with a median improvement rate of 4 (IQR 3\u20134). All patients reported a high degree of satisfaction (median 9) and tolerable pain (median 5). In conclusion, dual PDL\u2010Nd: YAG laser is a convenient, safe, and effective treatment option for mucocutaneous telangiectasia in HHT patients.<\/jats:p>","DOI":"10.1111\/dth.15124","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T04:27:23Z","timestamp":1630902443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Satisfactory treatment of mucocutaneous lesions in hereditary hemorrhagic telangiectasia patients with dual pulsed dye laser and neodymium: yttrium\u2013aluminum\u2013garnet"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-546X","authenticated-orcid":false,"given":"Xavier","family":"Cubir\u00f3","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Garcia\u2010Melendo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caridad Elena","family":"Morales\u2010Munera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Ro\u00e9\u2010Crespo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Riera\u2010Mestre","sequence":"additional","affiliation":[{"name":"Hereditary Hemorrhagic Telangiectasia Unit, Department of Internal Medicine Hospital Universitari de Bellvitge \u2013 IDIBELL, L'Hospitalet de Llobregat  Barcelona Spain"},{"name":"Faculty of Medicine and Health Sciences Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Mora\u2010Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Hereditary Hemorrhagic Telangiectasia Unit, Department of Internal Medicine Hospital Universitari de Bellvitge \u2013 IDIBELL, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Iriarte","sequence":"additional","affiliation":[{"name":"Hereditary Hemorrhagic Telangiectasia Unit, Department of Internal Medicine Hospital Universitari de Bellvitge \u2013 IDIBELL, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Puig","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eul\u00e0lia","family":"Baselga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Department of Dermatology Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat  Barcelona 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