{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:43:50Z","timestamp":1762508630086,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pityriasis rosea (PR) has been manifested in patients suffering from COVID\u201019 as well as after vaccine protocols against SARS\u2010CoV\u20102. It has a possible association with the HHV\u20106B virus (<jats:italic>roseola infantum<\/jats:italic>) and can be controlled by antivirals such as acyclovir as well as by the amino acid <jats:sc>l<\/jats:sc>\u2010Lysine that showed a positive result in reducing the number of lesions and healing time. The aim of this study was to report a case of PR after a second dose of Oxford\u2010AstraZeneca, the adopted therapy and a brief literature review. A 53\u2010year\u2010old woman, phototype II, presented an erythematous lesion in the posterior right thigh 15\u2009days after the second dose of Oxford\u2010AstraZeneca vaccine. Eight days after the initial injury, new injuries appeared in the calf, buttocks and thighs. The diagnosis was PR with a 5\u2010week eruption cycle. The treatment consisted of the use of <jats:sc>l<\/jats:sc>\u2010Lysine, 3 grams loading dose and 500\u2009mg for 30\u2009days and moisturizing\/healing lotion, starting 14\u2009days after the herald patch. After the 5th week of the disease cycle, there were no new eruptions and the repair cycle continued for up to 8\u2009weeks leaving some residual skin spots. It is concluded that the patient may be a carrier a latent virus, HHV\u20106, and the vaccine administration with immune system stimulation, would have activated the possible virus causing PR. <jats:sc>l<\/jats:sc>\u2010Lysine helped to control the manifestation by limiting the number of lesions and their location, which were restricted to the legs, thighs and buttocks.<\/jats:p>","DOI":"10.1111\/dth.15129","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T11:34:18Z","timestamp":1631878458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pityriasis rosea\u2010like cutaneous eruption as a possible dermatological manifestation after <scp>Oxford\u2010AstraZeneca<\/scp> vaccine: Case report and brief literature review"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-6626","authenticated-orcid":false,"given":"Maria Cristina","family":"Pedrazini","sequence":"first","affiliation":[{"name":"Professor \u2010 Department of Dental Sciences Faculdade de Odontologia e Centro de Pesquisas S\u00e3o Leopoldo Mandic  Campinas S\u00e3o Paulo State Brazil"},{"name":"Department of Biosciences Piracicaba Dental School \u2013 FOP \u2013 UNICAMP  Piracicaba S\u00e3o Paulo State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-8805","authenticated-orcid":false,"given":"Mariliza Henrique","family":"da Silva","sequence":"additional","affiliation":[{"name":"Infectious Disease Specialist \u2010 Department of Infectiology Diagnosis State Program STI\/AIDS Reference and Training Center of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.585354"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32661-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00234-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4799"},{"volume-title":"Coronavirus vaccine tracker","year":"2021","author":"Zimmer C","key":"e_1_2_8_8_1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01429-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj"},{"volume-title":"All UK \u2013 Spontaneous reports received between 04\/01\/21 and 16\/06\/21 for COVID\u201019 vaccine Oxford University\/AstraZeneca. 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