{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:44:54Z","timestamp":1790095494796,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["970609"],"award-info":[{"award-number":["970609"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Topical minoxidil solution is recommended treatment for female pattern hair loss. However, some complications, such as skin allergies, have prevented some patients from completely receiving this treatment. This study intends to evaluate the therapeutic and side effects of oral minoxidil 0.25\u2009mg tablets treatment on FPHL and compare it with conventional treatment of 2% topical minoxidil. This study is a triple\u2010blind randomized clinical trial in which 72 women with FPHL were treated as two separate groups. Group 1 was treated with oral minoxidil 0.25\u2009mg tablets and topical placebo solution, while topical minoxidil solutions and oral placebo tablets were used to treat group 2 patients. In the oral minoxidil group, the average hair diameter and hair density after the 9\u2010month treatment reached from 0.044\u2009mm and 102\u2009per\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    to 0.048\u2009mm and 115\u2009per\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    , respectively. In the topical minoxidil group, the average hair diameter and hair density from initial values of 0.044\u2009mm and 107\u2009per\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    increased to 0.047\u2009mm and 113\u2009per\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    . In both groups, the changes of hair diameter and hair density were significant compared to initial values (\n                    <jats:italic>p\u2009&lt;<\/jats:italic>\n                    \u00a00.001), while the trend of changes was not statically different between the two groups (\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u00a00.077,\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u00a00.674 for hair diameter and hair density, respectively) and side effects were trivial. In conclusion, oral minoxidil is an effective and new treatment for FPHL, even with a minimal dose, which can be used as an alternative treatment, especially for patients with poor compliance against topical minoxidil.\n                  <\/jats:p>","DOI":"10.1111\/dth.15131","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T08:44:51Z","timestamp":1631781891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A randomized clinical trial on therapeutic effects of 0.25\u2009mg oral minoxidil tablets on treatment of female pattern hair loss"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6583-6787","authenticated-orcid":false,"given":"Sadegh","family":"Vahabi\u2010Amlashi","sequence":"first","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-0922","authenticated-orcid":false,"given":"Pouran","family":"Layegh","sequence":"additional","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Kiafar","sequence":"additional","affiliation":[{"name":"Cutaneous Leishmaniasis Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Hoseininezhad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Abbaspour","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh Hajebi","family":"Khaniki","sequence":"additional","affiliation":[{"name":"Student Research Committee, Department of Biostatistics, School of Health Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Forouzanfar","sequence":"additional","affiliation":[{"name":"Electronics Group, Engineering Faculty Birjand University  Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-6137","authenticated-orcid":false,"given":"Vahideh","family":"Sabeti","sequence":"additional","affiliation":[{"name":"Resident of Dermatology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Dermatology Imam Reza Hospital  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7162.865"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13838"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5790"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1126"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S214907"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1303571"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.150743"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.66914"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660350088019"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.466"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11775.1"},{"issue":"3","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.adengl.2017.02.016","article-title":"New 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