{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:38:28Z","timestamp":1765888708056,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Androgenic alopecia (AGA) is a common and chronic condition. It may impact self\u2010esteem, self\u2010image and quality of life. Benefit, tolerability, cosmetic acceptance and patient satisfaction are key to ensure good treatment outcome. Hair loss improvement and hair quality with AC5 (2,4\u2010Diamino\u2010Pyrimidine\u2010N\u2010Oxyde, arginine, 6\u2010O glucose linoleate (SP94), piroctone olamine and Vichy mineralizing water) once daily was assessed in 527 subjects with mild AGA in an open\u2010label, observational, international real\u2010life study. After 3 months, investigators evaluated the impact of AC5 on hair loss, product satisfaction and asked subjects about local tolerance; subjects assessed hair growth and quality and satisfaction. Data from 357 subjects were evaluable for the benefit analysis; 59.9% of subjects were female; the mean age was 33.6\u00b18.7 years. Duration of hair loss was 1.62\u00b12.24 years. 71.3% of women had a Ludwig score of 1 and 40.8% of men had a Hamilton Norwood score of 2. At the end of study, hair loss was reduced in 89.0% of subjects; it was slightly higher in women (92.5%) than in men (83.8%). Subject satisfaction on a scale from 0 (not satisfied at all) to 10 (completely satisfied) was 7.9\u00b11.7. Tolerance was rated good to very good by 98.6% of all subjects. In conclusion, AC5 reduces mild AGA in both men and women with a pleasant texture. AC5 was well tolerated and highly appreciated.<\/jats:p>","DOI":"10.1111\/dth.15134","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T05:55:44Z","timestamp":1631858144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An anti\u2010hair loss treatment in the management of mild androgenetic alopecia: Results from a large, international observational study"],"prefix":"10.1155","volume":"34","author":[{"given":"Pascal","family":"Reygagne","sequence":"first","affiliation":[{"name":"Centre Sabouraud H\u00f4pital Saint\u2010Louis  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-6148","authenticated-orcid":false,"given":"Victor Desmond","family":"Mandel","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical and Experimental Medicine University of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Delva","sequence":"additional","affiliation":[{"name":"SyliaStat Lancrenon  Bourg\u2010la\u2010Reine France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Havl\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Poliklinika Chmelnice  Praha Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila","family":"Padlewska","sequence":"additional","affiliation":[{"name":"ORICEA Esthetic Dermatology &amp; Anti\u2010Aging Medicine  Warszawa Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Khalil","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Dahr Sarba Jounieh  Sarba Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Meuleman","sequence":"additional","affiliation":[{"name":"Private Practice  Tielt Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto Adame","family":"Miranda","sequence":"additional","affiliation":[{"name":"Del Valle Centro  Ciudad de M\u00e9xico, CDMX Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariya","family":"Nevskaya","sequence":"additional","affiliation":[{"name":"Trichology and Cosmetology Center of Tatyana Tsimbalenko  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Francois","family":"Michelet","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay\u2010sous\u2010Bois France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Pouradier","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Saint\u2010Ouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2773-7494","authenticated-orcid":false,"given":"Sergio","family":"Vano\u2010Galvan","sequence":"additional","affiliation":[{"name":"Trichology Unit. #TricoHRC Research Group, Department of Dermatology Ram\u00f3n y Cajal University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Kerob","sequence":"additional","affiliation":[{"name":"Laboratoires Vichy International  Levallois Perret France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153370"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"189","article-title":"Female pattern hair loss: current treatment concepts","volume":"2","author":"Dinh QQ","year":"2007","journal-title":"Clin Interv Aging"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/767628"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2017.01.001"},{"key":"e_1_2_9_6_1","first-page":"541","article-title":"Female pattern alopecia: current perspectives","volume":"5","author":"Levy LL","year":"2013","journal-title":"Int J Women's Health"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2012.12003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.3.311"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04195.x"},{"key":"e_1_2_9_11_1","first-page":"173","article-title":"Emotional benefit of cosmetic camouflage in the treatment of facial skin conditions: personal experience and review","volume":"5","author":"Levy LL","year":"2012","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"5","key":"e_1_2_9_12_1","first-page":"1","article-title":"Interest of a combination of Aminexil and arginine for male and female hair loss: a multicenter Italian study","volume":"146","author":"Piraccini B","year":"2011","journal-title":"G Ital Dermatol Venereol"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"1","article-title":"Tratamiento de la alopecias de patron masculino y femenino. 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