{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:22Z","timestamp":1787014102533,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psoriasis is a chronic autoimmune skin disorder that can vary in severity and extent of disease. While localized disease can be managed with topical medications, widespread disease often requires systemic therapy including biologics. This medication class targets different components of the immune system and thus modulates disease activity. The biologic secukinumab is a human monoclonal antibody against interleukin\u201017A used for the treatment of psoriasis and psoriatic arthritis; cases of inflammatory bowel disease (IBD) have been observed in clinical trials to be associated with this medication. This review aims to provide evidence for the relationships between secukinumab treatment and the development of IBD. We have examined review articles and original research papers, published between 2010 and 2020, using the following keywords: psoriasis, psoriatic arthritis, secukinumab, IBD, Crohn's disease, ulcerative colitis, interleukin\u201017, IL\u201017, IL\u201017 inhibitor. Case reports have noted an association between secukinumab use and IBD and have called for IBD pre\u2010screening in patients who will be prescribed this medication. Clinical trials concluded that secukinumab was associated with IBD, while retrospective studies have had mixed results, with most studies showing no statistical significance between secukinumab and IBD but having seen patients with history of IBD or family histories experience new\u2010onset IBD or flare\u2010ups. Given the utilization of secukinumab as a therapy for psoriasis and psoriatic arthritis, appropriate screening and risk stratification could help limit morbidity and mortality that can be associated with secukinumab\u2010induced IBD.<\/jats:p>","DOI":"10.1111\/dth.15151","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T22:29:54Z","timestamp":1633559394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["New onset inflammatory bowel disease in patient treated with secukinumab: Case report and review of literature"],"prefix":"10.1155","volume":"34","author":[{"given":"Ailia K.","family":"Ali","sequence":"first","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology Wake Forest School of Medicine  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Torosian","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology Wake Forest School of Medicine  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Porter","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology Wake Forest School of Medicine  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Bloomfeld","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology Wake Forest School of Medicine  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology Wake Forest School of Medicine  North Carolina USA"},{"name":"Department of Pathology Wake Forest School of Medicine  North Carolina USA"},{"name":"Department of Social Sciences &amp; Health Policy Wake Forest School of Medicine  North Carolina USA"},{"name":"Department of Dermatology University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.010"},{"issue":"9","key":"e_1_2_7_4_1","first-page":"720","article-title":"The onset of ulcerative colitis during treatment with secukinumab: can anti\u2010IL\u201017A be a trigger for inflammatory bowel disease?","volume":"111","author":"Rodr\u00edguez Moncada R","year":"2019","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214273"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15397"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2018.56"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-019-00803-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1329511"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.024"},{"key":"e_1_2_7_11_1","unstructured":"Cosentyxhttp:\/\/www.pharma.us.novartis.com\/product\/pi\/pdf\/cosentyx.pdf."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301668"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1882-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217927"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.298"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X19893580"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0422-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9679287"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9404505"},{"issue":"9","key":"e_1_2_7_20_1","first-page":"1131","article-title":"Emergence of inflammatory bowel disease during treatment with Secukinumab","volume":"12","author":"Fobelo Lozano MJ","year":"2018","journal-title":"J Crohns Colitis"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2017.07.001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i22.2734"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.15151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T08:10:17Z","timestamp":1713946217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.15151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/dth.15151"],"URL":"https:\/\/doi.org\/10.1111\/dth.15151","archive":["Portico"],"relation":{},"ISSN":["1396-0296","1529-8019"],"issn-type":[{"value":"1396-0296","type":"print"},{"value":"1529-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2021-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15151"}}