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Twenty patients with diabetic foot ulcers were divided into two groups: the control group receiving standard wound care and the plasma group, which received CAP twice a week for six consecutive weeks in addition to standard wound care. The ulcer size, amount of exudate, and wound grading were determined weekly. Cold plasma was produced by applying a high voltage (4.5\u00a0kV) and a high frequency (22\u2009kHz) to helium gas. Exudate from wounds treated with CAP showed a significant reduction in the third week after complete treatment (<jats:italic>p<\/jats:italic>\u00a0=\u20090.039). The wound grading of the ulcers improved by the sixth week (<jats:italic>p<\/jats:italic>\u00a0=\u20090.019), and the sizes of ulcers significantly decreased in the plasma group at the end of the treatment period (<jats:italic>p<\/jats:italic>\u00a0=\u20090.007). In this randomized clinical trial, CAP was an effective treatment option for diabetic foot ulcers in terms of wound surface reduction and antibacterial effects.<\/jats:p>","DOI":"10.1111\/dth.15169","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T05:53:13Z","timestamp":1634881993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The evaluation of efficacy of atmospheric pressure plasma in diabetic ulcers healing: A randomized clinical trial"],"prefix":"10.1155","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-5363","authenticated-orcid":false,"given":"Shirin","family":"Samsavar","sequence":"first","affiliation":[{"name":"Physics Department Shahid Beheshti University  Tehran 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