{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:23:15Z","timestamp":1789759395406,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atrophic acne scars are the most common cutaneous seqaule of acne vulgaris, representing 80%\u201390% of all acne scars. Ablative fractional carbon dioxide (FCO\n                    <jats:sub>2<\/jats:sub>\n                    ) laser is the gold standard treatment for atrophic scars. Additionally, platelet\u2010rich plasma (PRP) is suggested to accelerate the healing process and collagen synthesis. The aim of the present systematic review and meta\u2010analysis was to determine the efficacy and safety of PRP combined with Ablative FCO\n                    <jats:sub>2<\/jats:sub>\n                    laser in the treatment of moderate to severe atrophic acne scars. Randomized controlled trials (RCTs) that have compared PRP in combination with ablative FCO\n                    <jats:sub>2<\/jats:sub>\n                    laser to ablative FCO\n                    <jats:sub>2<\/jats:sub>\n                    laser alone with respect to the efficacy and safety measures were included. We have systematically explored Embase, Medline, and CENTRAL databases via Ovid. The outcomes that our systematic review sought to evaluate were clinical improvement, patient satisfaction, and Goodman and Baron's qualitative acne scar score. The dichotomous outcomes were presented as odds ratio (OR) while the continuous outcomes were presented as standardized mean difference (SMD). Eleven RCTs that represents 313 participants were included. The combined use of laser and PRP showed a statistically significant clinical improvement and patient satisfaction compared to the use of laser alone (OR\u00a0=\u00a02.56, 95% CI 1.37\u20134.78 and OR\u00a0=\u00a03.38, 95% CI 1.80\u20136.34, respectively). Also, a significant improvement in Goodman and Baron's score was achieved by combining PRP with laser (SMD\u00a0=\u00a0\u22120.40, 95% CI \u20130.65 to \u22120.14). The combined treatment of laser and PRP was highly synergistic, effective, and safe in treating moderate to severe atrophic acne scars.\n                  <\/jats:p>","DOI":"10.1111\/dth.15888","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T23:33:15Z","timestamp":1664667195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ablative fractional carbon dioxide laser combined with autologous platelet\u2010rich plasma in the treatment of atrophic acne scars: A systematic review and meta\u2010analysis"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6017-0835","authenticated-orcid":false,"given":"Yara E.","family":"Aljefri","sequence":"first","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Ghaddaf","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana A.","family":"Alahmadi","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taif A.","family":"Alkhamisi","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tala A.","family":"Alkhunani","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-8924","authenticated-orcid":false,"given":"Sahal J.","family":"Samarkandy","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"},{"name":"Department of Dermatology King Abdulaziz Medical City  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-8614","authenticated-orcid":false,"given":"Awadh M.","family":"Alamri","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"},{"name":"Department of Dermatology King Abdulaziz Medical City  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","first-page":"734","article-title":"Diagnosis and treatment of acne","volume":"86","author":"Titus S","year":"2012","journal-title":"Am Fam 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