{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:02:01Z","timestamp":1788829321114,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["99\u20101\u2010101\u201046059"],"award-info":[{"award-number":["99\u20101\u2010101\u201046059"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rituximab (RTX) combined with short\u2010term glucocorticoids (GC) is an effective therapeutic option for pemphigus. The newly developed Glucocorticoid Toxicity Index (GTI) tool provides the possibility to measure GC toxicities over time. To compare 1\u2010year GTI between two groups of RTX\u2010treated and RTX\u2010na\u00efve patients with pemphigus. The responsiveness of the GTI was also investigated. A prospective cohort of 129 adults with newly diagnosed pemphigus was conducted. GC\u2010related toxicities were assessed at 3\u2010month intervals according to Composite and Specific lists of the GTI. Of the patients, 76.7% (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200999) received RTX. Throughout the time intervals, RTX\u2010treated patients had lower GTI compared to RTX\u2010na\u00efve ones (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.036). The mean GTI at 1\u2010year was 34.3 in the RTX\u2010treated group and 50.8 in the RTX\u2010na\u00efve group (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.04). The most commonly observed GC\u2010related toxicity was neuropsychiatric manifestations for 34% (224 events). The relapse rate of RTX\u2010treated patients (1%) was significantly lower than RTX\u2010na\u00efve patients (10%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.037). The GTI showed no correlation with cumulative GC consumption in both groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&gt;\u20090.05, both). Patients treated with GC alone had remarkably higher GTI than patients treated with GC plus RTX. The GTI is an applicable tool to quantitatively capture GC toxicities at the patient level in pemphigus.\n                  <\/jats:p>","DOI":"10.1111\/dth.15902","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T08:41:19Z","timestamp":1665045679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Applicability of glucocorticoid toxicity index in pemphigus: Comparison between two groups of rituximab\u2010treated and rituximab\u2010na\u00efve patients"],"prefix":"10.1155","volume":"35","author":[{"given":"Elham","family":"Mazaherpour","sequence":"first","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-0598","authenticated-orcid":false,"given":"Nika","family":"Kianfar","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-5098","authenticated-orcid":false,"given":"Shayan","family":"Dasdar","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Seyrafi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Balighi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Saberi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-1858","authenticated-orcid":false,"given":"Ali","family":"Nili","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Farimani","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedram Molhem","family":"Azar","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-1005","authenticated-orcid":false,"given":"Hamidreza","family":"Mahmoodi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2971-0199","authenticated-orcid":false,"given":"Dedee F.","family":"Murrell","sequence":"additional","affiliation":[{"name":"Department of Dermatology St George Hospital  Sydney New South Wales Australia"},{"name":"Faculty of Medicine University of New South Whales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-8895","authenticated-orcid":false,"given":"Maryam","family":"Daneshpazhooh","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1670059"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1617831"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31778-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092163"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00703-2018"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0432"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.11.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1881-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01418"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_1078_14"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16752"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30070-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2018.12.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.021"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18482"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210002"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13016"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00206-1"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.205"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0343-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/JW9.0000000000000056"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1510173"},{"key":"e_1_2_12_25_1","first-page":"1","article-title":"Rituximab in childhood and juvenile autoimmune bullous diseases as first\u2010line and second\u2010line treatment: a case series of 13 patients","volume":"7","author":"Kianfar N","year":"2020","journal-title":"J Dermatolog Treat"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/JW9.0000000000000038"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_290_18"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217871"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.12.043"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.032"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.08.032"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2021.09.003"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.15902","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:37:40Z","timestamp":1788154660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.15902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/dth.15902"],"URL":"https:\/\/doi.org\/10.1111\/dth.15902","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"2022-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15902"}}