{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:05:58Z","timestamp":1791230758269,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Skin aging goes beyond a chronological process and also results from extrinsic factors referred to as the exposome. Hyaluronic acid (HA) is an important component of the extracellular matrix, with loss starting at 25\u2009years old. While many studies of HA concern topical use, few literature reviews only address the use of topical HA in dermatology. This review describes the different characteristics of HA\u2010containing cosmeceuticals, with a focus on skin aging and the impact of exposome factors on HA synthesis and degradation. A review was performed using the terms HA, hyaluronan, topical, dermatology, cosmetic, aging treatment, exposome, and cosmeceuticals. Results are also presented from a recent randomized controlled trial (RCT), which investigated the additional benefit of using a HA epidermic filler (HA\u2010filler serum) combined with Botulinum toxin type A (BoNTA) to treat signs of skin aging. Subjects were randomized to two groups: HA\u2010filler serum starting 24\u2009h after the BoNTA injection then twice daily for 24\u2009weeks, or the control group, which received BoNTA. HA is a key ingredient used in cosmeceuticals for its hydration\/antiaging properties (hygroscopic, rheological, and viscoelastic). Several clinical studies indicate that HA is both well tolerated and effective, adjuvant to both post\u2010surgical and facial rejuvenation procedures. In the RCT, one of few studies to combine BoNTA and HA with a 6\u2010month follow\u2010up, the HA\u2010filler serum lengthened the duration of BoNTA's effect in reducing wrinkles. Numerous studies support HA\u2010based cosmeceuticals as a noninvasive, effective solution for improving skin hydration and rejuvenation.<\/jats:p>","DOI":"10.1111\/dth.15903","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T10:05:10Z","timestamp":1665050710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":169,"title":["Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-7967","authenticated-orcid":false,"given":"Bruna","family":"Bravo","sequence":"first","affiliation":[{"name":"Bravo's Clinic  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-3678","authenticated-orcid":false,"given":"Priscila","family":"Correia","sequence":"additional","affiliation":[{"name":"Scientific Expertise, Cosmetic Active L'Or\u00e9al Brasil  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-4426","authenticated-orcid":false,"given":"Jos\u00e9 Euz\u00e9bio","family":"Gon\u00e7alves Junior","sequence":"additional","affiliation":[{"name":"Scientific Expertise, Cosmetic Active L'Or\u00e9al Brasil  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-0665","authenticated-orcid":false,"given":"Beatriz","family":"Sant'Anna","sequence":"additional","affiliation":[{"name":"Scientific Expertise, Cosmetic Active L'Or\u00e9al Brasil  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-4261","authenticated-orcid":false,"given":"Delphine","family":"Kerob","sequence":"additional","affiliation":[{"name":"Cosmetic Active International L'Or\u00e9al  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.03.007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0456"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2478\/cipms-2019-0027"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S177448"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15583"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.204"},{"key":"e_1_2_11_8_1","volume-title":"StatPearls [Internet]","author":"Pandey A","year":"2021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.21923"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.11.066"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12120"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119127"},{"key":"e_1_2_11_13_1","unstructured":"BravoB CorreiaP Gon\u00e7alves J\u00faniorJE et al.Randomized controlled study to assess the additional benefit of a dermocosmetic with hyaluronic acid and Vitamin C combined with Botulinum toxin for skin aging signs. 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