{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:41:02Z","timestamp":1789062062763,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alopecia areata (AA) is a disease that affects the psychological well\u2010being of the affected individuals. Laser\u2010assisted drug delivery and microneedling (MN) are promising methods for the treatment of different dermatological diseases. The aim of the study was to compare the efficacy of topical application of triamcinolone acetonide after fractional carbon dioxide laser versus MN in the treatment of resistant AA from a clinical and dermoscopic perspective. Thirty patients were randomly divided into two groups of 15 patients each: the Laser group received fractional CO\n                    <jats:sub>2<\/jats:sub>\n                    laser treatment followed by topical application of triamcinolone acetonide, and the MN group received dermapen treatment followed by topical application of triamcinolone acetonide. In our study, we found no statistically significant difference between the studied groups before and after treatment, except for black dot, which is higher in the MN group than in the laser group (46.7% vs. 13.3%). There is a statistically significant difference between the studied groups in terms of treatment response at the first follow\u2010up, with 13.3% of the laser group seeing terminal hair regrowth compared to 0 in the MN group after 12\u2009weeks. Regarding the degree of improvement, there was no statistically significant difference between the laser group and the MN group. The use of fractional CO\n                    <jats:sub>2<\/jats:sub>\n                    laser and MN for transepidermal drug delivery (TED) allowed for more uniform drug distribution. There was no significant difference between the two treatment methods in terms of their high effectiveness in the treatment of resistant AA.\n                  <\/jats:p>","DOI":"10.1111\/dth.15913","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T06:39:20Z","timestamp":1665297560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparative study between topical application of triamcinolone acetonide after fractional carbon dioxide laser versus microneedling in the\u00a0treatment of resistant alopecia areata"],"prefix":"10.1155","volume":"35","author":[{"given":"Mai Mohamed","family":"Omar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria Mahran","family":"Obaid","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology, and Andrology Faculty of Medicine Al\u2010Azhar University  Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Magdy Elshahat","family":"Sayedahmed","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology, and Andrology Faculty of Medicine Al\u2010Azhar University  Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_96_18"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.1142"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"Treatment of alopecia areata in pre\u2010adolescent children with oral tofacitinib: a retrospective study","volume":"00","author":"Jerjen R","year":"2020","journal-title":"Pediatr Dermatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.12.019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2014.967778"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13742"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"413","article-title":"Ophiasis alopecia areata treated with microneedling","volume":"33","author":"Asad U","year":"2020","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb03230.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_73_20"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1525743"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01999.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14722"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2015.0160"},{"issue":"3","key":"e_1_2_9_15_1","first-page":"521","article-title":"Intralesional triamcinolone acetonide versus platelet\u2010rich plasma: a comparative study in the treatment of alopecia areata of the scalp","volume":"5","author":"Ranpariya RH","year":"2019","journal-title":"Int J Res"},{"issue":"4","key":"e_1_2_9_16_1","first-page":"1030","article-title":"Alopecia areata universalis: hair regrowth with fractioned CO2 laser therapy","volume":"4","author":"Cris\u00f3stomo M","year":"2017","journal-title":"J Autoimmun Res"},{"key":"e_1_2_9_17_1","first-page":"6","article-title":"Triamcinolone acetonide mesotherapy in the treatment of recalcitrant patches of alopecia areata\u2014a pilot study","volume":"2","author":"Chandrashekar BS","year":"2015","journal-title":"J Clin Dermatol Ther"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.129989"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.110767"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.15913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:36:26Z","timestamp":1788154586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.15913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/dth.15913"],"URL":"https:\/\/doi.org\/10.1111\/dth.15913","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"2022-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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