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The IgE secretion, airway hypersensitivity, and effector cell recruitment (eosinophils, mast cells, basophils) in skin lesion and peripheral blood stream could be upregulated during the activation of type 2 immune response. Th1\/Th2 ratio, also referred as Th1\/Th2 balance, represent the T lymphocytes immune pattern to a certain degree: Th1\u2010dominated responses are often involved in intracellular infections (e.g., mycobacterium tuberculosis) and autoimmune diseases (e.g., Graves' disease) while Th2\u2010dominated responses are involved in allergic conditions (e.g., atopic dermatitis, eczema), IgE mediated diseases (e.g., urticaria), and fibrotic dermatoses (e.g., keloids). Dupilumab, as one of the most widely applied Th2 cytokine inhibitors, could block the bioactivity of IL\u201014\/IL\u201013 via competitively binding to the common IL\u20104R\u03b1 subunit shared by IL\u20104 and IL\u201013 receptors. In addition to the direct inhibition of type 2 response, dupilumab is also effective in autoimmune and some infectious skin diseases through indirect regulation of type 1 immune response. The pathological mechanism of Th2 responses and advanced clinical application of dupilumab in skin diseases will be summarized and discussed in the review.<\/jats:p>","DOI":"10.1111\/dth.15924","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T12:10:59Z","timestamp":1665490259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dupilumab: Advances in the off\u2010label usage of\n                    <scp>IL4<\/scp>\n                    \/\n                    <scp>IL13<\/scp>\n                    antagonist in dermatoses"],"prefix":"10.1155","volume":"35","author":[{"given":"Fengming","family":"Jia","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan 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