{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:36:07Z","timestamp":1788428167097,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acne scarring usually causes cosmetic and psychological problems. Our aim of the study was to compare the efficacy of microneedling alone, intradermal injection of platelet rich plasma (PRP) alone and combined microneedling with PRP in the treatment of atrophic post\u2010acne scars. Thirty adult patients with facial post\u2010acne scars were randomly recruited and divided into two groups: A and B. Group A: included 15 patients; the left sides of their faces were treated with microneedling by dermapen followed by PRP while on the right side of the faces microneedling alone was performed. Group B: included 15 patients; the left sides of their faces were treated with microneedling by dermapen followed by PRP while the right sides of the faces were treated with intradermal injection of PRP. For both groups, the treatment session was repeated every 3\u2009weeks until clearance of the atrophic acne scars or for four sessions maximally. Patients' evaluation was done pre\u2010treatment and 3\u2009weeks after the last session by photography, Goodman and Baron qualitative grading system and Echelle d'Evaluation Clinique des Cicatrices d'Acn\u00e9 (ECCA) scale. By using all of these evaluation methods, group A showed that there was better improvement on the left side but without statistical significant difference. However, group B showed that there was a significant reduction in the total number of post\u2010acne scars on the left side compared to the right side by using photographic assessment and ECCA grading scale. Skin microneedling, PRP and combined microneedling with PRP are effective therapeutic modalities in atrophic post\u2010acne scars treatment. However, combined microneedling with PRP gives better results and is better tolerated in all types of atrophic acne scars.<\/jats:p>","DOI":"10.1111\/dth.15925","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T12:09:14Z","timestamp":1665490154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Which is more effective in atrophic acne scars treatment microneedling alone or platelet rich plasma alone or combined both therapeutic modalities?"],"prefix":"10.1155","volume":"35","author":[{"given":"Sahar A.","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanis A. H.","family":"Khella","sequence":"additional","affiliation":[{"name":"Police Hospital  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa A. E.","family":"Abou\u2010Taleb","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33252.x"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"43","article-title":"Treatment of acne scars using fractional erbium: YAG laser","volume":"3","author":"Al\u2010Saedy SJ","year":"2014","journal-title":"Am J Dermatol Venereol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.18410\/jebmh\/2015\/1256"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"The management of atrophic acne scars: overview and new tools","volume":"51","author":"Fabbrocini G","year":"2012","journal-title":"J Clin Exp Dermatol 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management of atrophic acne scars: tips for the general dermatologist","volume":"4","author":"Fife D","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12095"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.742949"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01999.x"},{"issue":"8","key":"e_1_2_10_18_1","first-page":"864","article-title":"Platelet\u2010rich plasma versus CROSS technique with 100% trichloroacetic acid versus combined skin needling and platelet rich plasma in the treatment of atrophic acne scars: a comparative study","volume":"40","author":"Nofal E","year":"2014","journal-title":"Dermatol Surg"},{"key":"e_1_2_10_19_1","first-page":"364","article-title":"Combination treatment of skin needling, platelet\u2010rich plasma and glycolic acid 70% chemical peeling for atrophic acne scars in Fitzpatrick's skin type IV\u2013VI","volume":"7","author":"Tantari SHW","year":"2016","journal-title":"J Clin Exp Dermatol Res"},{"issue":"8","key":"e_1_2_10_20_1","first-page":"268","article-title":"A comparative study of efficacy of micro\u2010needling alone versus micro\u2010needling with autologous platelet rich plasma in facial atrophic acne scars","volume":"3","author":"Yadav CK","year":"2017","journal-title":"IMJ Health"},{"issue":"4","key":"e_1_2_10_21_1","first-page":"177","article-title":"Combined use of skin needling and platelet\u2010rich plasma in acne scarring treatment","volume":"24","author":"Fabbrocini G","year":"2011","journal-title":"Cosmet Dermatol"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.174378"},{"key":"e_1_2_10_23_1","first-page":"1458","article-title":"Postacne scarring: a qualitative global scarring grading system","volume":"32","author":"Goodman's GJ","year":"2006","journal-title":"Dermatol 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