{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:24Z","timestamp":1788156924196,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psoriasis is a chronic, immune\u2010mediated inflammatory disease for which no definitive cure exists and patients difficult to treat with moderate to severe psoriasis often require life\u2010long therapy. In general, the use of any biologic agent as monotherapy allows a long\u2010term efficacy, however survival response may progressively decrease over time. We report real\u2010world long lasting response data in psoriatic patients on treatment with anti\u2010TNF\u03b1 evaluating those on the same anti\u2010TNF\u03b1 agent (infliximab, etanercept, adalimumab) from January 2011 and December 2013 to December 31, 2021 as monotherapy. On 210 treated patients, 69 were found to maintain the same anti\u2010TNF\u03b1 agent. The median survival rate for etanercept, infliximab and adalimumab was 10, 9.6, and 9.5\u2009years respectively and the efficacy rate was similar (mean PASI96). Our results demonstrate that anti\u2010TNF\u03b1 agents are a long\u2010term effective and safe therapeutic option for a satisfying proportion (33%) of patients with moderate\u2010to\u2010severe chronic plaque psoriasis. Further long\u2010term real life studies are needed to better understand which are the causes of drug failure or persistent response and why these may occur at different time intervals in patients on the same drug.<\/jats:p>","DOI":"10.1111\/dth.15956","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T03:23:17Z","timestamp":1666408997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long lasting response to anti\u2010tumor necrosis factor \u03b1 agents in psoriasis: A real life experience"],"prefix":"10.1155","volume":"35","author":[{"given":"Maria Letizia","family":"Musumeci","sequence":"first","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Calogero","family":"Trecarichi","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania 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