{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:24Z","timestamp":1788156924910,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Benvitimod is a topical drug that has recently been approved for mild to moderate psoriasis and atopic dermatitis. The drug has just completed phase 3 trials for psoriasis, which calls for a systematic update of current evidence on the efficacy and safety of this drug. We searched MEDLINE (PubMed), EMBASE, Science Direct, International Clinical Trials Registry Platform (ICTRP), Cochrane Central Register of Controlled Trials, and Google Scholar for all available randomized controlled trials concerning the topic. We included six randomized controlled trials evaluating the efficacy of benvitimod 1.0% with a total of 1925 patients. Our meta\u2010analysis demonstrated that more patients in the benvitimod group achieved physician global assessment score of 0 or 1 (RR 6.53, 95% CI 4.39\u20139.71), psoriasis area and severity index (PASI) 75 (RR 4.34, 95% CI 2.96\u20136.36), PASI 90 (RR 8.83, 95% CI 5.22\u201314.95) and body surface area reduction (MD \u22123.85, 95% CI \u22124.83, \u22122.88) than placebo at week 12. Patient\u2010reported outcomes were also analyzed, yielding a significant benefit in the benvitimod group for peak pruritus numerical rating scale (PP\u2010NRS) score (MD \u22121.20, 95% CI \u22121.98, \u22120.42), \u22654\u2010point decrease in PP\u2010NRS score (RR 1.58, 95% CI, 1.24\u20132.03) and dermatology life quality index score (MD \u22122.54, 95% CI \u22124.00, \u22121.07). There was a significantly higher incidence of adverse events in the benvitimod group compared to placebo (RR 1.98, 95% CI 1.73\u20132.27), while the risk was found to be non\u2010significant for serious adverse events. Benvitimod is an effective treatment of psoriasis as compared to a placebo. However, more large\u2010scale, high\u2010quality trials are needed to comment on the safety of this drug.<\/jats:p>","DOI":"10.1111\/dth.15957","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T13:40:25Z","timestamp":1666618825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Benvitimod for the treatment of psoriasis: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-2342","authenticated-orcid":false,"given":"Muhammad","family":"Ehsan","sequence":"first","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqeeb Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3191-9373","authenticated-orcid":false,"given":"Farwa","family":"Athar","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biah","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haseeba","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-7137","authenticated-orcid":false,"given":"Huzaifa Ahmad","family":"Cheema","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-7956","authenticated-orcid":false,"given":"Muhammad","family":"Ayyan","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abia","family":"Shahid","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzair","family":"Jafar","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-1179","authenticated-orcid":false,"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"issue":"9","key":"e_1_2_11_2_1","first-page":"626","article-title":"Psoriasis","volume":"87","author":"Weigle N","year":"2013","journal-title":"Am Fam Physician"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61909\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32549\u20106"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2018.05.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011535.pub2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15104"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.13.163"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1615\/critrevtherdrugcarriersyst.2013005268"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2021.2016699"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2021.09.005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103629"},{"key":"e_1_2_11_15_1","unstructured":"PRISMA. 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