{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:08:00Z","timestamp":1788815280966,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Melasma is a recurrent hypermelanosis disorder characterized by the appearance of brownish and symmetrical spots on the skin. It affects the quality of life and is resistant to available treatment approaches. Cysteamine has been reported as a promising depigmenting agent for melasma treatment and following formulation enhancement, its use is being reported. This review aimed to evaluate the efficacy of the use of depigmenting formulations containing 5% cysteamine in the treatment of patients with melasma. A systematic search was performed in PubMed, Science Direct, and Scielo databases until December 27, 2021, based on criteria selected by the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. Statistical analysis was performed with Review Manager 5.4 software. The risk of bias was assessed using the Cochrane Risk of Bias Tool for Randomized Trials. A total of six studies containing 120 melasma patients treated with 5% cysteamine were included in this meta\u2010analysis. The meta\u2010analysis demonstrated that 5% cysteamine is effective for the treatment of patients with melasma (MD 6.26 [95% CI 3.68\u20138.83],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a086%). In this review, through meta\u2010analysis allows concluding that 5% cysteamine is effective in the treatment of melasma and presents a low probability of side or adverse effects.\n                  <\/jats:p>","DOI":"10.1111\/dth.15961","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T02:16:07Z","timestamp":1666750567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is cysteamine use effective in the treatment of melasma? A systematic review and meta\u2010analysis"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-1456","authenticated-orcid":false,"given":"Agenor Gomes","family":"dos Santos\u2010Neto","sequence":"first","affiliation":[{"name":"Department of Morphology and Experimental Pathology Institute of Technology and Research  Aracaju Sergipe Brazil"},{"name":"Health and Environment Postgraduate Program Tiradentes University  Aracaju Sergipe Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdsis Carolline Val\u00e9rio","family":"da Silva","sequence":"additional","affiliation":[{"name":"School of Medicine Tiradentes University  Aracaju Sergipe Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlisson Ramos","family":"Melo","sequence":"additional","affiliation":[{"name":"Health and Environment Postgraduate Program Tiradentes University  Aracaju Sergipe Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilson Allef Moraes","family":"Santana","sequence":"additional","affiliation":[{"name":"Health and Environment Postgraduate Program Tiradentes University  Aracaju Sergipe Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Luiz Cavalcanti","family":"de Albuquerque\u2010Junior","sequence":"additional","affiliation":[{"name":"Department of Morphology and Experimental Pathology Institute of Technology and Research  Aracaju Sergipe Brazil"},{"name":"Health and Environment Postgraduate Program Tiradentes University  Aracaju Sergipe Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2012.05748.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.84722"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13059"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100749.2003.00005.x"},{"key":"e_1_2_10_6_1","first-page":"115","article-title":"Classifica\u00e7\u00e3o do melasma pela dermatoscopia: estudo comparativo com l\u00e2mpada de Wood","volume":"1","author":"Barcau\u00ed CB","year":"2009","journal-title":"Surg Cosm Dermatol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365\u201005962009000600008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2011.04430.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010018\u20101861\u20105"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2009.03778.x"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"53","article-title":"Melasma in men: a review of clinical, etiological, and management issues","volume":"11","author":"Sarkar R","year":"2018","journal-title":"J Clin Aesthet Dermatol"},{"issue":"4","key":"e_1_2_10_12_1","first-page":"245","article-title":"Skin diseases seen in Kazanchis health center","volume":"36","author":"Hiletework M","year":"1998","journal-title":"Ethiop Med J"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256\u20104947.1998.558"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.3.424"},{"key":"e_1_2_10_15_1","first-page":"545","article-title":"Nosologic profile of dermatologic visits in Brazil","volume":"81","author":"Sociedade Brasileira de Dermatologia SBD","year":"2006","journal-title":"Clin Epidemiol Lab Ther Investig"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0365\u201005962013000100009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010017\u20100194\u20101"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010020\u201001637\u2010x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.57602"},{"issue":"11","key":"e_1_2_10_20_1","first-page":"1316","article-title":"Treatment of melasma and the use of intense pulsed light: a review","volume":"11","author":"Zaleski L","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2010.01523.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2017.01.004"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.1996.tb00345.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.1365"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2012.04464.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20102077.118403"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S191964"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.04.003"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100749.2006.00334.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2019.07.003"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030832"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17043902"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2000.00826.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.6367"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8294158"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12837"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104\u201011692007000300023"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15146"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010020\u201002133\u20107"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12901"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1351608"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13424"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13432"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13844"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022\u2010202X.2004.22239.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06\u20106649rev"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15104"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2008.02885.x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb02329.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2009.00912.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12080"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11\u2010201376"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.106082"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440701638970"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.02.003"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.051"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12109"},{"issue":"1","key":"e_1_2_10_59_1","first-page":"177","article-title":"Effect of Cysteamine on cell growth and IgG4 production in recombinant Sp2.0 cells","volume":"14","author":"Jahandar H","year":"2015","journal-title":"Iran J Pharm Res"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910799"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.15961","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:37:22Z","timestamp":1788154642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.15961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/dth.15961"],"URL":"https:\/\/doi.org\/10.1111\/dth.15961","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"2022-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15961"}}