{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:21Z","timestamp":1788156921943,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although oral isotretinoin has been considered as a potential therapeutic option for the treatment of different types of warts, the optimum dosage regimen is not yet well\u2010established. To evaluate the efficacy and adverse effects of high versus low doses of oral isotretinoin in the treatment of cutaneous and genital warts. The study included 100 patients who were randomly assigned to two groups, 50 patients in each. Group 1 received 0.6\u00a0mg\/kg\/day (high dose isotretinoin) and Group 2 received 0.3\u00a0mg\/kg\/day (low dose isotretinoin). In both groups, therapy was given daily until resolution was achieved or for a maximum of 3\u00a0months. Complete clearance of warts was observed in 76% of the high dose isotretinoin group and in 46% of the low dose isotretinoin group. There was a statistically significant difference in the therapeutic response between the two groups. Recurrence was higher in the low dose group (26%) than the high dose group (7.8%). Adverse effects were mild and tolerable. High dose of systemic isotretinoin is more effective than low dose and seems to be a promising well\u2010tolerated and effective therapeutic option for the treatment of cutaneous and genital warts.<\/jats:p>","DOI":"10.1111\/dth.15964","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T08:34:02Z","timestamp":1667896442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High versus low dose oral isotretinoin in the treatment of cutaneous and genital warts"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5899-7195","authenticated-orcid":false,"given":"Ahmad","family":"Nofal","sequence":"first","affiliation":[{"name":"Dermatology Department School of Medicine, Zagazig University  Zagazig Egypt"},{"name":"Member of Interactive Dermatology Research Group  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-4715","authenticated-orcid":false,"given":"Mohamed M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Member of Interactive Dermatology Research Group  Cairo Egypt"},{"name":"Dermatology Department Faculty of Medicine, Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Eldeeb","sequence":"additional","affiliation":[{"name":"Dermatology Department School of Medicine, Zagazig University  Zagazig Egypt"},{"name":"Member of Interactive Dermatology Research Group  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hager","family":"Nofal","sequence":"additional","affiliation":[{"name":"Dermatology Department School of Medicine, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa E.","family":"El\u2010Hawary","sequence":"additional","affiliation":[{"name":"Dermatology Department Faculty of Medicine, Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.4.4.273"},{"key":"e_1_2_8_3_1","first-page":"182","article-title":"A new chapter of dermatotherapy","volume":"44","author":"Tsambaos D","year":"1996","journal-title":"Derm Beruf Umwelt"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000056361"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12836"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1808152"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/163929"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13673"},{"key":"e_1_2_8_9_1","first-page":"1810","article-title":"Treatment of condylomata acuminate with oral isotretinoin","volume":"158","author":"Tsambaos D","year":"1997","journal-title":"Clin Urol"},{"key":"e_1_2_8_10_1","first-page":"358","article-title":"Complete remission of recalcitrant viral warts under oral isotretinoin in a patient with low\u2010grade B\u2010cell lymphoma","volume":"85","author":"Monastirli A","year":"2004","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"35","article-title":"Extensive and recalcitrant common warts in an immunocompetent patient: rapid and complete remission after oral isotretinoin monotherapy","volume":"29","author":"Pasmatzi E","year":"2020","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.869302"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70127-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2003.006841"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13727"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12059"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.15964","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:37:31Z","timestamp":1788154651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.15964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/dth.15964"],"URL":"https:\/\/doi.org\/10.1111\/dth.15964","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,11]]},"assertion":[{"value":"2022-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15964"}}