{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:48:47Z","timestamp":1792889327106,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is a lack of efficacious topical treatments for patients suffering from psoriatic nail disease (PND). We investigated the efficacy of Calcipotriol\u2010Betamethasone Dipropionate (Cal\/BD) foam with and without ablative fractional laser (AFL) in patients with PND. A total of 144 nails from 11 patients were treated in a 24\u2010week long, open\u2010label, randomized, intra\u2010patient controlled proof\u2010of\u2010concept hybrid trial. In addition to daily Cal\/BD foam application, half of each patient's psoriatic nails were randomized to receive optical coherence tomography (OCT)\u2010guided AFL treatment at baseline, 6\u2010, and 12\u2010week follow\u2010ups.\n                    <jats:italic>In\u2010clinic<\/jats:italic>\n                    assessment (N\u2010NAIL), patient\u2010reported outcomes (PROMs), and drug consumption were supplemented by\n                    <jats:italic>remote<\/jats:italic>\n                    evaluation of 15 subclinical OCT features, smartphone app\u2010based safety monitoring, and photo\u2010based assessment (NAPSI). After 24\u2009weeks of Cal\/BD foam treatment, patients achieved a significant improvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in both clinical (N\u2010NAIL \u221276%, NAPSI \u221268%) and subclinical (OCT \u221243%) PND severity as well as a 71% reduction in PROMs. AFL\u2010assisted Cal\/BD treatment led to higher clinical (N\u2010NAIL \u221285%, NAPSI \u221278%) and OCT\u2010assessed (\u221246%) reduction of PND signs than Cal\/BD alone (N\u2010NAIL \u221266%, NAPSI \u221258%, OCT \u221237%), but did not reach statistical significance. Smartphone app images documented adverse events and mild local skin reactions, particularly erythema (75%), laser\u2010induced swelling (28%), and crusting (27%). This hybrid trial demonstrated a reduction in clinical NAPSI and N\u2010NAIL scores, subclinical OCT features, and PROMs, suggesting that Cal\/BD foam is a safe and efficacious treatment for PND. Larger trials are warranted to prove the clinical benefit of AFL pretreatment as a Cal\/BD delivery enhancer.\n                  <\/jats:p>","DOI":"10.1111\/dth.15965","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T07:33:09Z","timestamp":1667374389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Investigating the efficacy and safety of calcipotriol\/betamethasone dipropionate foam and laser microporation for psoriatic nail disease\u2014A hybrid trial using a smartphone application, optical coherence tomography, and\n                    <scp>patient\u2010reported<\/scp>\n                    outcome measures"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-6717","authenticated-orcid":false,"given":"Vinzent Kevin","family":"Ortner","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"LEO Pharma A\/S  Ballerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-6148","authenticated-orcid":false,"given":"Victor Desmond","family":"Mandel","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia  Modena Italy"},{"name":"Porphyria and Rare Diseases Unit San Gallicano Dermatological Institute \u2013 IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kresten","family":"Skak","sequence":"additional","affiliation":[{"name":"LEO Pharma A\/S  Ballerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-8303","authenticated-orcid":false,"given":"John Robert","family":"Zibert","sequence":"additional","affiliation":[{"name":"Future\u2010Brain Aps  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Bourlioux","sequence":"additional","affiliation":[{"name":"Omhu A\/S LEO Innovation Lab  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5961-9399","authenticated-orcid":false,"given":"Christoffer Valdemar","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3329-2516","authenticated-orcid":false,"given":"Christine Sofie Krohn","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9656-733X","authenticated-orcid":false,"given":"Peter Alshede","family":"Philipsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-2035","authenticated-orcid":false,"given":"Merete","family":"Haedersdal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14351"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2020.12.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002835"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16426"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.15171\/jlms.2020.02"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1476647"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2017.3173"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2637691"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3296"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.09.009"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478257"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333362"},{"key":"e_1_2_11_14_1","first-page":"185","article-title":"Randomized 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Halobetasol 0.01%\/tazarotene 0.045% fixed\u2010combination lotion in the treatment of plaque psoriasis: sensitization and irritation potential.J Clin Aesthet Dermatol. 2019;12(1):11\u201015."},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_11_48_1","unstructured":"Enstilar Cutaneous Foam \u2010 Summary of Product Characteristics (SmPC) \u2010 (emc).https:\/\/www.medicines.org.uk\/emc\/product\/2139\/smpc#gref."},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17027"},{"key":"e_1_2_11_50_1","unstructured":"Elewski B.An Investigator Initiated Study Evaluating the Efficacy and Tolerability of Enstilar Foam (Calcipotriene and Betamethasone Dipropionate) in Patients with Nail Psoriasis.2021.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04227288."},{"key":"e_1_2_11_51_1","unstructured":"Florez A.Observational and Prospective Study in Patients with Nail Psoriasis Treated with Calcipotriene and Betamethasone Dipropionate Aerosol Foam to Evaluate the Change in the Severity of Psoriasis and in the Quality of Life.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04380597(2021)."},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12923"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23304"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506418"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.15965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:37:27Z","timestamp":1788154647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.15965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/dth.15965"],"URL":"https:\/\/doi.org\/10.1111\/dth.15965","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,23]]},"assertion":[{"value":"2022-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15965"}}