{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:07:18Z","timestamp":1790381238668,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatologic Therapy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is a paucity of data about the impact of systemic statins on vitiliginous lesions in non\u2010segmental vitiligo (NSV) patients. To the best of our knowledge, no other studies have considered the correlation between lipid disturbances in vitiligo and vitiligo disease activity (VIDA) score. We sought in this study to evaluate the influence of simvastatin on vitiliginous lesions in NSV patients with dyslipidemia and study the correlation between VIDA score and lipid profile. This clinical trial started with 120 patients with NSV, 79 patients had dyslipidemia and received simvastatin 80\u2009mg daily (till normalization of lipid profile or for 4\u00a0months, which came first) and only 63 patients continued till the end of the study. Lipid profile, vitiligo area severity index and VIDA were assessed before and 6\u00a0months after the end of simvastatin use. Serum total cholesterol (TC), triglycerides, high\u2010density lipoprotein (HDL), low\u2010density lipoprotein (LDL), very low\u2010density lipoprotein, and LDL\/HDL ratio showed statistically significant increases in the NSV than in the control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a00.001). There was a statistically significant positive correlation between VIDA and serum levels of TC and LDL and with LDL\/HDL ratio. Simvastatin significantly improved the lipid profile and significantly decreased VIDA (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.011). Negative moderate correlation was found between the decrease in VIDA and duration of disease (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.562,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Simvastatin 80\u2009mg daily could be a helpful treatment for NSV patients with dyslipidemia, controlling the vitiligo activity and protecting against the hazardous effects of dyslipidemia. Better results can be obtained in patients with short duration of the disease.\n                  <\/jats:p>","DOI":"10.1111\/dth.15969","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T06:54:11Z","timestamp":1667890451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Simvastatin and\n                    <scp>non\u2010segmental<\/scp>\n                    vitiligo: A new potential treatment option?"],"prefix":"10.1155","volume":"35","author":[{"given":"Engi Seif E.","family":"Shaker","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-8772","authenticated-orcid":false,"given":"Sherihan H.","family":"Allam","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaly M.","family":"Mabrouk","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa M.","family":"Elgharbawy","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Endocrinology Unit, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-4238","authenticated-orcid":false,"given":"Shady Fikry Abdel","family":"Salaam","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1090","volume-title":"Bolognia Textbook of Dermatology","author":"Passeron T","year":"2018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791526105"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2017.71114"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101141"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"19","article-title":"Hepato\u2010splenic and lipid profile abnormalities \u2013 do they exist in children affected with vitiligo?","volume":"22","author":"Pietrzak A","year":"2014","journal-title":"Acta Dermatovenerol Croatica"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0163\u20107258(99)00045\u20105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010018\u20103168\u20104"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.12.009"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2019.07.006"},{"key":"e_1_2_11_12_1","first-page":"269","article-title":"Comparison of serum lipid in girls affected with vitiligo and control group","volume":"55","author":"Pietrzak A","year":"2000","journal-title":"Ann Univ Mariae Curie Sklodowska Med"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5455\/ijmsph.2016.1008201590"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1203"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.2010.03972"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.048"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08\u2010116327"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.2004.01524.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.01.020"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u2010511x\u20103\u20107"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.529"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.6401"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.06.015"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277\u20109175.203159"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)31357\u20105"}],"container-title":["Dermatologic Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dth.15969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dth.15969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:37:06Z","timestamp":1788154626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dth.15969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/dth.15969"],"URL":"https:\/\/doi.org\/10.1111\/dth.15969","archive":["Portico"],"relation":{},"ISSN":["1396-0296"],"issn-type":[{"value":"1396-0296","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,9]]},"assertion":[{"value":"2022-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15969"}}