{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:57:35Z","timestamp":1767664655937,"version":"3.41.2"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"OPM (Otto Per Mille) Chiesa Evangelica Valdese"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Cancer Care"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a population of patients referred for fertility preservation (FP), how to efficiently provide FP care, and how FP care changed over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal observational study enrolled 281 female cancer patients referred between 2013 and 2016 to the non\u2010profit organisation Gemme Dormienti ONLUS (GD) for FP care. All patients underwent the same battery of instrumental and laboratory diagnostic tests. GnRHa therapy was started at least seven days before CTh treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2013 to 2016, we observed a progressive increase in the number of patients referred for FP care. Out of 251 eligible patients, 135 patients were treated with GnRHa only, and 72 patients underwent GnRHa therapy and cryopreservation. The median time from GD referral to oocyte and ovarian tissue cryopreservation was 11 and 5\u00a0days respectively. Tissue cryopreservation requests increased during our study period (from four cases in 2013 to 17 cases in 2016). During follow\u2010up, 17\u03b2\u2010estradiol and FSH levels were significantly increased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), and AMH levels were significantly decreased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rapid increase in the number of patients who requested FP care and in the complexity of FP procedures overtime reflects the need to improve quality of life for cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ecc.13174","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T06:23:37Z","timestamp":1569911017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preliminary results of a counselling programme for fertility preservation in female cancer patients: The experience of the GEMME DORMIENTI network"],"prefix":"10.1155","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-5684","authenticated-orcid":false,"given":"Mariavita","family":"Ciccarone","sequence":"first","affiliation":[{"name":"Department of Gynaecology San Carlo di Nancy Hospital Rome Italy"},{"name":"Gemme Dormienti Association ONLUS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Hohaus","sequence":"additional","affiliation":[{"name":"Policlinico Gemelli Foundation Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pulsoni","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnology and Haematology Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cavaceppi","sequence":"additional","affiliation":[{"name":"LabAurelia Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Franz\u00f2","sequence":"additional","affiliation":[{"name":"Gemme Dormienti Association ONLUS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Gynaecology and Physiopathology of Human Reproduction Unit Department of Medical and Surgical Sciences S.Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cudillo","sequence":"additional","affiliation":[{"name":"Haematology and Stem Cell Transplant Unit Tor Vergata University Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Battistini","sequence":"additional","affiliation":[{"name":"A.O. 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