{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:02:49Z","timestamp":1789664569430,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Cancer Care"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the cardio\u2010respiratory response to exercise and examine the relationships among specific measures of cardio\u2010respiratory function, energy expenditure (EE), fatigue and adiposity in children survivors of acute lymphoblastic leukaemia (ALL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy survivors of ALL (13.31\u00a0\u00b1\u00a02.60\u00a0years) and 34 controls from the siblings (12.71\u00a0\u00b1\u00a02.36\u00a0years) participated and were assessed for submaximal and maximal exercise capacity, body composition, EE and fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ALL survivors had significantly lower submaximal (VO<jats:sub>2<\/jats:sub>; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and maximal (VO<jats:sub>2peak<\/jats:sub>; <jats:italic>p\u00a0<\/jats:italic>\u02c2\u00a00.001) cardio\u2010respiratory capacity than their controls. At the submaximal exercise test, EE was significantly lower in ALL survivors (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), but the heart rate (HR) was significantly higher (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). The VO<jats:sub>2<\/jats:sub> and HR were significantly correlated [<jats:italic>r<\/jats:italic> (95%CI)\u00a0=\u00a00.689 (0.542 to 0.795), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001]. The VO<jats:sub>2peak<\/jats:sub> negatively associated with adiposity [<jats:italic>r<\/jats:italic> (95%CI)\u00a0=\u00a0\u22120.368 (\u22120.554 to \u22120.145), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002]. Fatigue significantly correlated with the VO<jats:sub>2peak<\/jats:sub> [<jats:italic>r<\/jats:italic> (95%CI)\u00a0=\u00a00.581 (0.401 to 0.718), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001] and adiposity [<jats:italic>r<\/jats:italic> (95%CI)\u00a0=\u00a0\u22120.303 (\u22120.502 to 0.073), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children survivors of ALL experience low cardio\u2010respiratory fitness within 5\u2010year off\u2010chemotherapy. Associations exist between measures of cardio\u2010respiratory fitness, EE, fatigue and adiposity. However, it has not yet been proven whether these are cause or effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ecc.13418","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T05:50:52Z","timestamp":1612245052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Within 5\u2010year off\u2010chemotherapy: How the cardio\u2010respiratory response to exercise is related to energy expenditure, fatigue, and adiposity in children with acute lymphoblastic leukaemia?"],"prefix":"10.1155","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-702X","authenticated-orcid":false,"given":"Ragab K.","family":"Elnaggar","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Health Rehabilitation College of Applied Medical Sciences Prince Sattam Bin Abdulaziz University Al\u2010Kharj Saudi Arabia"},{"name":"Department of Physical Therapy for Pediatrics Faculty of Physical Therapy Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/24694193.2017.1316791"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00073"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/h06-014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460600687382"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2993-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0024"},{"issue":"3","key":"e_1_2_8_8_1","first-page":"353","article-title":"Cardiorespiratory fitness of obese boys","volume":"49","author":"Chatterjee S.","year":"2005","journal-title":"Indian Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28388"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"164","article-title":"Mechanisms of fatigue","volume":"8","author":"Davis M. 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