{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:20:58Z","timestamp":1778628058507,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:00:00Z","timestamp":1351036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Aim: The aim of this study was to compare cardiac structure and function in patients with chronic atrial fibrillation (<jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>), as opposed to patients with paroxysmal atrial fibrillation (<jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>), and normal control subjects. Methods and Results: This study included 83 patients, divided into 3 groups: group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, 32 patients with <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> for \u22656\u00a0months; group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, 29 patients in sinus rhythm with a documented history of <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>; and group <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, 22 patients without history of atrial fibrillation. Patients with <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> were older (71\u00a0years vs. 64 in group B, and 64 in group C). Apart from age, groups were clinically similar. After careful clinical evaluation, comprehensive echocardiography studies were performed including cardiac chambers' size, systolic and diastolic left ventricular function. Left atrium (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) volume index was significantly larger in <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> and control patients: 39\u00a0\u00b1\u00a013 versus 34\u00a0\u00b1\u00a09 versus 25\u00a0\u00b1\u00a08 (P\u00a0&lt;\u00a00.003). Left ventricular ejection fraction was lower in <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>: 53.8\u00a0\u00b1\u00a07 versus 61.6\u00a0\u00b1\u00a06.7 versus 58.4\u00a0\u00b1\u00a05.2% (P\u00a0&lt;\u00a00.001). Isovolumic relaxation time was shorter in <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>, 65\u00a0\u00b1\u00a016 versus 82\u00a0\u00b1\u00a021 versus 81\u00a0\u00b1\u00a013\u00a0msec (P\u00a0&lt;\u00a00.001). E\/Vp was significantly greater in <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> 2.6\u00a0\u00b1\u00a00.8 versus 1.7\u00a0\u00b1\u00a00.4 versus 1.7\u00a0\u00b1\u00a00.5 (P\u00a0&lt;\u00a00.001). Additional diastolic parameters were also significantly different. Conclusion: These findings demonstrate that in patients with <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> structural and functional cardiac changes occur. Patients with <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> as opposed to both normal subjects and patients with <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> have larger left atria and reduced systolic and diastolic left ventricular function.<\/jats:p>","DOI":"10.1111\/echo.12003","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T08:19:02Z","timestamp":1351066742000},"page":"140-146","source":"Crossref","is-referenced-by-count":6,"title":["Does Chronic Atrial Fibrillation Induce Cardiac Remodeling?"],"prefix":"10.1111","volume":"30","author":[{"given":"Therese","family":"Fuchs","sequence":"first","affiliation":[{"name":"Arrhythmia and Echocardiography Service Department of Cardiology Assaf Harofeh Medical Center Zerifin Israel"},{"name":"Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvera L.","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Medicine Mount Sinai School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Leitman","sequence":"additional","affiliation":[{"name":"Arrhythmia and Echocardiography Service Department of Cardiology Assaf Harofeh Medical Center Zerifin Israel"},{"name":"Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Burgsdorf","sequence":"additional","affiliation":[{"name":"Arrhythmia and Echocardiography Service Department of Cardiology Assaf Harofeh Medical Center Zerifin Israel"},{"name":"Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amram","family":"Torjman","sequence":"additional","affiliation":[{"name":"Business School College of Management Rishon\u2010Le\u2010Zion Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Vered","sequence":"additional","affiliation":[{"name":"Arrhythmia and Echocardiography Service Department of Cardiology Assaf Harofeh Medical Center Zerifin Israel"},{"name":"Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01236-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60040-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.812347"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-08-0508"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2685"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021328"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021375"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00332-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.2.476"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.158931"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708789"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0608"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03230-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.023"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90836-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.941"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00979.x"},{"key":"e_1_2_6_20_1","first-page":"223","article-title":"Effect of atrial fibrillation on left ventricular function in the elderly","volume":"113","author":"Wysokinski A","year":"2005","journal-title":"Pol Arch Med Wewn"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.02.067"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: A Report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification. 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