{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:37:25Z","timestamp":1762623445962},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) is associated with elevated cardiovascular risk even during childhood. Tissue <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler is a sensitive technique for the assessment of ventricular dysfunction with relatively little data available in children with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. We report a prospective cross\u2010sectional echocardiographic study at a tertiary center. Forty\u2010nine patients with median (range) age 11.2\u00a0years (6.9\u201317.9), weight 39.6\u00a0kg (23.6\u201399.7) and height 146\u00a0cm (122\u2013185). Thirty\u2010one patients were male. Median duration of follow\u2010up for <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> was 7.1\u00a0years (range 0.13\u201316.9). Patients were in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 3 (n\u00a0=\u00a037) or 4 (n\u00a0=\u00a012). Mitral valve E\u2010wave, A\u2010wave, and E\/A ratio showed mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) z\u2010scores of 0.08 (0.93), 0.12 (0.82) and \u22120.13 (0.84), respectively. Tissue Doppler imaging (TDI) at the lateral mitral valve annulus showed e\u2032, a\u2032, s\u2032, and E\/e\u2032 z\u2010scores mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) \u22121.10 (0.76), \u22120.29 (0.92), \u22121.2 (0.7), and 0.86 (1.1), respectively. There was a significant negative correlation of e\u2032 and s\u2032 z\u2010score with patient age. E\/e\u2032 ratio correlated positively with patient age. Blood pressure, left ventricular mass, and relative wall thickness did not correlate with tissue Doppler measurements. The e\u2032 and s\u2032 velocities correlated significantly with each other, suggesting an interaction of systolic and diastolic dysfunction. Children with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> may have abnormalities of systolic and diastolic ventricular function on TDI, which are not evident on blood pool Doppler. The tissue Doppler results are consistent with worsening ventricular function in older patients.<\/jats:p>","DOI":"10.1111\/echo.12015","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T13:33:33Z","timestamp":1353418413000},"page":"331-337","source":"Crossref","is-referenced-by-count":19,"title":["Systolic and Diastolic Ventricular Function Assessed by Tissue Doppler Imaging in Children with Chronic Kidney Disease"],"prefix":"10.1111","volume":"30","author":[{"given":"John M.","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Congenital Heart Disease Evelina Children's Hospital, Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Rawlins","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease Evelina Children's Hospital, Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujeev","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease Evelina Children's Hospital, Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Chubb","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease Evelina Children's Hospital, Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish D.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology Evelina Children's Hospital, Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(98)70145-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031643"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.10"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3282fb7bf2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060609"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep211"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04690510"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.03.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2009.01124.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00525.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2009.05.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2010.01249.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0734-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.168377"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.2.259"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.1416"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.S2.555"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2003.12.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.6.667"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90385-Z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.03.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000150108.37527.57"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.661983"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03433-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp570"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.023"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02921-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200501000-00029"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.112334"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.08.048"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.04.054"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.244"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01561.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.010"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.2.121"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.12015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.12015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:02:26Z","timestamp":1697662946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.12015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/echo.12015"],"URL":"https:\/\/doi.org\/10.1111\/echo.12015","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}