{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:39:18Z","timestamp":1715596758420},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Background: There is growing evidence that aortic distensibility (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a subclinical marker of early atherosclerosis. Aortic intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) was an earlier marker than carotid <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> of preclinical atherosclerosis. In this study, we aimed to assess the relationship between thoracic aortic <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Methods: We studied 192 patients (mean age: 45.5\u00a0\u00b1\u00a08.4\u00a0years) who underwent transesophageal echocardiography (<jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content>) for various indications. Four different grades were determined according to <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> of thoracic aorta (Grade 1\u00a0&lt;\u00a01\u00a0mm; 1\u00a0mm\u00a0\u2264\u00a0Grade 2\u00a0&lt;\u00a03\u00a0mm; 3\u00a0mm\u00a0\u2264\u00a0Grade 3\u00a0&lt;\u00a05\u00a0mm; 5\u00a0mm\u00a0\u2264\u00a0Grade 4). <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements in all patients. High sensitive <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein (hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and other biochemical markers were measured using an automated chemistry analyzer. Results: <jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content> evaluation characterized thoracic aortic intimal morphology as grade 1 in 71 patients (37%), grade 2 in 57 patients (29.7%), grade 3 in 34 patients (17.7%), and grade 4 in 30 (15.6%) patients. The lowest <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> level was observed in grade 4 group compared with grade 1 and grade 2 groups (P\u00a0&lt;\u00a00.001, P\u00a0=\u00a00.009, respectively). <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> level of grade 3 group was lower than grade 1 and grade 2 group (P\u00a0&lt;\u00a00.001, P\u00a0=\u00a00.021, respectively). In multiple linear regression analysis, <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was independently associated with age (\u03b2\u00a0=\u00a0\u22120.138, P\u00a0=\u00a00.029), hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.209, P\u00a0=\u00a00.001), and aortic <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.432, P\u00a0&lt;\u00a00.001). Conclusion: <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> is independently associated with age, thoracic aortic <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>, and hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>. Impaired elasticity index of the aorta might be an independent predictor for the severity of thoracic atherosclerosis.<\/jats:p>","DOI":"10.1111\/echo.12066","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T02:15:51Z","timestamp":1355278551000},"page":"407-413","source":"Crossref","is-referenced-by-count":5,"title":["Aortic Distensibility and Aortic Intima\u2010Media Thickness in Patients without Clinical Manifestation of Atherosclerotic Cardiovascular Disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Zafer","family":"Elbasan","sequence":"first","affiliation":[{"name":"Department of Cardiology Adana Numune Education and Research Hospital Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durmu\u015f Y\u0131ld\u0131ray","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Adana Numune Education and Research Hospital Adana 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