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Two\u2010dimensional <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> is a relatively angle independent technology that can measure global and regional strain, strain rate, displacement, and velocity in longitudinal, radial, and circumferential directions. It can also quantify rotational movements such as rotation, twist, and torsion of the myocardium. Two\u2010dimensional <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> has been validated against hemodynamics, tissue Doppler, tagged magnetic resonance imaging, and sonomicrometry studies. Two\u2010dimensional <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> has been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early subclinical changes in various pathologies. A large number of studies have evaluated the role of 2<jats:styled-content style=\"fixed-case\">D STE<\/jats:styled-content> in predicting response to cardiac resynchronization therapy in patients with severe heart failure. However, the clinical utility of 2D <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> in the above mentioned conditions remains controversial because of conflicting reports from different studies. Emerging areas of application include prediction of rejection in heart transplant patients, early detection of cardiotoxicity in patients receiving chemotherapy for cancer, and effect of intracoronary injection of bone marrow stem cells on left ventricular function in patients with acute myocardial infarction. The emerging technique of three\u2010dimensional <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> may further extend its clinical usefulness.<\/jats:p>","DOI":"10.1111\/echo.12079","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T23:05:37Z","timestamp":1357686337000},"page":"88-105","source":"Crossref","is-referenced-by-count":173,"title":["Two\u2010 and Three\u2010Dimensional Speckle Tracking Echocardiography: Clinical Applications and Future Directions"],"prefix":"10.1111","volume":"30","author":[{"given":"Monodeep","family":"Biswas","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvin","family":"Sudhakar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham 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