{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T18:42:16Z","timestamp":1770576136353,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Right ventricular (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) pacing is associated with left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) dysfunction. However, the effects of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> pacing at different sites on both <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> function have rarely been studied before. We want to determine whether different <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> pacing sites differentially affect <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> deformation by using speckle tracking echocardiography (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were 73 patients who had undergone dual\u2010chamber permanent pacemaker implantation and did not have structural heart diseases. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> global longitudinal strains (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>) were measured using <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> to determine subtle changes in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function. Twenty\u2010three patients without pacing after pacemaker implantation served as controls; 14 and 36 patients showed apical and septal pacing, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant intergroup demographic differences. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> biplane ejection fractions in the septal\u2010 and apical\u2010pacing groups were significantly lower than those in the controls. The <jats:styled-content style=\"fixed-case\">GLS<jats:sub>LV<\/jats:sub><\/jats:styled-content> values were similar between the control and septal\u2010pacing groups, but they were lower in the apical\u2010pacing group. Multivariate analysis revealed that cumulative pacing loads and apical pacing were independent factors associated with lower <jats:styled-content style=\"fixed-case\">GLS<jats:sub>LV<\/jats:sub><\/jats:styled-content> values. The <jats:styled-content style=\"fixed-case\">GLS<jats:sub>RV<\/jats:sub><\/jats:styled-content> values were similar between the control and apical\u2010pacing groups; however, they were lower in the septal\u2010pacing group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that patients with septal pacing have significantly higher <jats:styled-content style=\"fixed-case\">GLS<jats:sub>LV<\/jats:sub><\/jats:styled-content> and more modest decreases in <jats:styled-content style=\"fixed-case\">GLS<jats:sub>RV<\/jats:sub><\/jats:styled-content> values than patients with apical pacing. Thus, septal pacing may be not necessarily preferable in patients without significant heart disease undergoing dual\u2010chamber permanent pacemaker implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12146","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T08:38:47Z","timestamp":1361781527000},"page":"812-819","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010Term Effect of Septal or Apical Pacing on Left and Right Ventricular Function after Permanent Pacemaker Implantation"],"prefix":"10.1111","volume":"30","author":[{"given":"Ju\u2010Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Division of Cardiology Department of Internal Medicine National Cheng Kung University Hospital Tainan 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