{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:19:05Z","timestamp":1789913945168,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary hypertension (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) is an important complication in the natural history of chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>) and is caused by the remodeling of pulmonary arteries impairing the distensibility and stiffness of the major pulmonary arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the pulmonary artery distensibility by transthoracic echocardiography in patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We prospectively investigated <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> male patients and compared with healthy controls. In addition to right ventricle (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) conventional echocardiographic parameters, right pulmonary artery fractional shortening(<jats:styled-content style=\"fixed-case\">RPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>) and new pulmonary artery stiffness (<jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>) parameters were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients participated in the study and compared with a control group consisting of 24, all men, healthy, nonsmoking subjects. Six patients were excluded from study due to poor quality of echocardiographic recordings. The distensibility of <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> evaluated by the <jats:styled-content style=\"fixed-case\">RPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> parameter was found to be significantly lower in patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> than it was in normal subjects (13.3\u00a0\u00b1\u00a08.1 vs. 27.6\u00a0\u00b1\u00a04.9,P\u00a0:&lt;\u00a00.001) and correlated positively with tricuspid annular systolic excursion (<jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content>) (r\u00a0=\u00a00.566, P\u00a0&lt;\u00a00.001) and pulmonary acceleration time (r\u00a0=\u00a00.607, P\u00a0&lt;\u00a00.001) and correlated inversely with pulmonary artery systolic pressure (r\u00a0=\u00a0\u22120.587, P\u00a0&lt;\u00a00.001), <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>(r\u00a0=\u00a0\u22120.479, P\u00a0&lt;\u00a00.001) and functional capacity (r\u00a0= \u22120.586, P\u00a0&lt;\u00a00.001). Similar to this, <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content> found to be impaired in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients (29.5\u00a0\u00b1\u00a013.6 vs. 15.7\u00a0\u00b1\u00a04.1, P\u00a0&lt;\u00a00.001) and correlated inversely <jats:styled-content style=\"fixed-case\">RPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> (r\u00a0=\u00a0\u22120.479, P\u00a0&lt;\u00a00.001). There were statistically significant difference for pulmonary artery distensibility (<jats:styled-content style=\"fixed-case\">RPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content> parameters among the <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> subgroups with regard to <jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content> functional capacity (P\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we found that <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content> and distensibility were worsened in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients and correlated with decreased functional capacity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12170","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:33:28Z","timestamp":1363221208000},"page":"940-944","source":"Crossref","is-referenced-by-count":22,"title":["Pulmonary Artery Distensibility in Chronic Obstructive Pulmonary Disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Cagatay","family":"Ertan","sequence":"first","affiliation":[{"name":"Department of Cardiology Acibadem University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan","family":"Tarakci","sequence":"additional","affiliation":[{"name":"Department of Chest Disease Acibadem University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozcan","family":"Ozeke","sequence":"additional","affiliation":[{"name":"Department of Cardiology Acibadem University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Duran","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Cardiology Acibadem University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200203000-00001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2011.100449"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1130OC"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059855"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12061"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945011794751483"},{"key":"e_1_2_5_8_1","first-page":"681","article-title":"The reason for tihe shape of the distensibility curves of arteries","volume":"35","author":"Roach MR","year":"1957","journal-title":"Can J Biochem"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.27.5.660"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.4.1080"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.258.6.H1823"},{"key":"e_1_2_5_12_1","first-page":"92","article-title":"A new echocardiographic approach in assessing pulmonary vascular bed in patients with congenital heart disease: Pulmonary artery stiffness","volume":"3","author":"G\u00f6rg\u00fcl\u00fc S","year":"2003","journal-title":"Anadolu Kardiyol Derg"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.4.657"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00055-8"},{"key":"e_1_2_5_16_1","first-page":"301","article-title":"Assessment of right ventricular function using two dimensional echocardiography","volume":"128","author":"Kaul S","year":"1984","journal-title":"Am Heart J"},{"key":"e_1_2_5_17_1","first-page":"157","volume-title":"Pulmonary Circulation","author":"Weitzenblum E","year":"1996"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200969090-00002"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-006OC"},{"issue":"5","key":"e_1_2_5_20_1","first-page":"S7","article-title":"BTS guidelines for the management of chronic obstructive pulmonary disease. 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