{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:28Z","timestamp":1787169628771,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Left atrial (\n                      <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                      ) size is known to increase with chronically increased left ventricular (\n                      <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n                      ) filling pressure. We hypothesized that\n                      <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                      volume was predictive of aortic valve replacement (\n                      <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>\n                      ) and cardiovascular events in a large cohort of patients with asymptomatic mild to moderate aortic valve stenosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Transthoracic echocardiography was performed in 1,758 patients in the Simvastatin and Ezetemibe in Aortic Stenosis study.\n                      <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                      volume was measured in the apical four\u2010chamber view in 1,503 patients (85%). The relation of\n                      <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                      volume to\n                      <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>\n                      or a combined endpoint of cardiovascular events (\n                      <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>\n                      , congestive heart failure due to aortic stenosis or death from cardiovascular causes) was evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>\n                      was performed in 415 (28%) patients, whereas 505 (34%) reached the combined endpoint. A significant but weak association of increased\n                      <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                      volume and risk of the combined endpoint was found (log\u2010rank test: P\u00a0=\u00a00.02), but this relation did not reach any significance in a multivariate model adjusting for age, gender, aortic valve area index,\n                      <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n                      ejection fraction,\n                      <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n                      hypertrophy, hypertension, and mitral regurgitation.\n                      <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                      volume was not predictive of\n                      <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>\n                      (log\u2010rank test: P\u00a0=\u00a00.3).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In asymptomatic patients with mild to moderate Aortic valve stenosis (\n                      <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\n                      ),\n                      <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                      volume was not predictive of the combined endpoint of Aortic valve replacement, development of heart failure or cardiac death.\n                      <jats:styled-content style=\"fixed-case\">AVA<\/jats:styled-content>\n                      and presence of\n                      <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n                      hypertrophy were the only predictors of events in multivariate analysis.\n                    <\/jats:p>\n                  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