{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:32:35Z","timestamp":1768735955158,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T00:00:00Z","timestamp":1366329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Fabry disease (FD) is characterized by left ventricular hypertrophy (<jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>). Conventional echocardiography is not sensitive enough to perform the preclinical diagnosis To assess whether longitudinal myocardial strain of the left ventricle (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>), using speckle tracking, is useful to detect early myocardial involvement in FD. Forty\u2010four patients with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> who were diagnosed with genetic testing were prospectively included and were compared to a sex\u2010matched control group. They were divided into three groups: 22 with <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> (Group I), 22 without <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> (Group II), and 22 healthy volunteers (Group III). <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal strain was measured from the apical views. An <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> test was used for multiple comparisons for variables with a normal distribution, and a Kruskal\u2013Wallis test was used for variables with non\u2010Gaussian distribution. Longitudinal <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> strain was different in the three groups: it was \u2265\u221215% in at least one segment in all Group I patients, in 50% of patients of Group II and in no patient of Group III. Seventy percent of the segments with abnormal strain in Group II were located in the basal regions (32\/46). These findings show that the presence of at least one strain value \u2265\u221215% demonstrates subclinical myocardial dysfunction in patients with preclinical FD. Longitudinal myocardial <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> strain measured with speckle tracking is a useful tool to detect early myocardial involvement in young patients with FD. This information allows the detection and treatment of myocardial dysfunction at an early stage, which is of high clinical importance.<\/jats:p>","DOI":"10.1111\/echo.12216","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T09:24:54Z","timestamp":1366363494000},"page":"1069-1077","source":"Crossref","is-referenced-by-count":53,"title":["Two\u2010Dimensional Speckle Tracking Echocardiography for Early Detection of Myocardial Damage in Young Patients with Fabry Disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Mar\u00eda C.","family":"Saccheri","sequence":"first","affiliation":[{"name":"Cardiology Department Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s F.","family":"Cianciulli","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Lax","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo L.","family":"C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Center for Fabry Disease Community Hospital of Pinamar Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra E.","family":"Quarin","sequence":"additional","affiliation":[{"name":"Center for Fabry Disease 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