{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:56:40Z","timestamp":1776999400363,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,12]],"date-time":"2013-05-12T00:00:00Z","timestamp":1368316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent advances in echocardiography have allowed assessment of flow velocity in the epicardial coronary arteries of patients with ischemic heart disease, using transthoracic color Doppler echocardiography (<jats:styled-content style=\"fixed-case\">TTDE<\/jats:styled-content>). However, few data are available regarding coronary blood flow in patients with hypertrophic cardiomyopathy (<jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the epicardial coronary arteries of patients with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A group of 25 patients with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> was assessed prospectively (mean age 57\u00a0\u00b1\u00a021\u00a0years, 11 male) using <jats:styled-content style=\"fixed-case\">TTDE<\/jats:styled-content>; flow velocities in the epicardial coronary arteries were measured and compared with those obtained in 10 age\u2010 and gender\u2010matched controls. Analysis of the diastolic spectral waveform included flow velocity integral (<jats:styled-content style=\"fixed-case\">VTI<\/jats:styled-content>), peak velocity, deceleration time, and deceleration slope measurements, while systolic waveform analysis included peak flow measurement and morphology assessment (positive, absent or negative). An analysis of variance (<jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>) test was used for multiple comparisons for variables with a normal distribution, and a Kruskal\u2013Wallis test was used for variables with non\u2010Gaussian distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> exhibited an increase in diastolic flow velocity with a rapid deceleration slope and a systolic slope which was decreased, absent or reversed, compared to normal subjects. On linear regression analysis there was no correlation with the type of hypertrophy or magnitude of the intraventricular pressure gradient in patients with obstructive <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>, noninvasive assessment with <jats:styled-content style=\"fixed-case\">TTDE<\/jats:styled-content> revealed abnormal findings in the distal flow of the epicardial coronary arteries, very similar to those seen in the no\u2010reflow phenomenon. These findings were independent of the type of hypertrophy and magnitude of the intraventricular pressure gradient in patients with obstructive <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12242","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T04:10:42Z","timestamp":1368418242000},"page":"1156-1163","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of Coronary Flow with Transthoracic Color Doppler Echocardiography in Patients with Hypertrophic Cardiomyopathy"],"prefix":"10.1111","volume":"30","author":[{"given":"Daniel E.","family":"Ferreiro","sequence":"first","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s F.","family":"Cianciulli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Saccheri","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Lax","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Celano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia R.","family":"Kazeli\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of the Government of the City of Buenos Aires \u201cDr. Cosme Argerich,\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto 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