{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:04:57Z","timestamp":1789034697219,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:00:00Z","timestamp":1372809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Chronic right ventricular apical (<jats:styled-content style=\"fixed-case\">RVA<\/jats:styled-content>) pacing can lead to an increased risk of heart failure and atrial fibrillation, but the acute effects of <jats:styled-content style=\"fixed-case\">RVA<\/jats:styled-content> pacing on left atrial (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) function are not well known. Twenty\u2010four patients with sick sinus syndrome and intact intrinsic atrioventricular conduction were included. All patients received dual\u2010chamber pacemaker implants with the atrial lead in the right atrial appendage and the ventricular lead in the right ventricular (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) apex. Transthoracic standard and strain echocardiography (measured by tissue Doppler imaging and speckle tracking image) were performed to identify functional changes in the left ventricle (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> before and after 1\u00a0hour of <jats:styled-content style=\"fixed-case\">RVA<\/jats:styled-content> pacing. The <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volume index did not change after pacing; however, the ratio of peak early diastolic mitral flow velocity (E) to peak early diastolic mitral annular velocity (Ea) was significantly increased and peak systolic <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> strain (Sm), mean peak systolic <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> strain rate (Sm<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>), peak early diastolic <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> strain rate (Em<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>), and peak late diastolic <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> strain rate (Am<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>) were significantly reduced after <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> pacing. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dyssynchrony, induced by <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> pacing, had a significant correlation with E\/Ea, Sm, and Sm<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> after pacing. E\/Ea also had a negative correlation with Sm and Sm<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> after pacing. Multivariate regression analysis identified <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dyssynchrony and E\/Ea as important factors that affect Sm, Sm<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>, Em<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>, and Am<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> after acute <jats:styled-content style=\"fixed-case\">RVA<\/jats:styled-content> pacing. Acute <jats:styled-content style=\"fixed-case\">RVA<\/jats:styled-content> pacing results in <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> functional change and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dyssynchrony and higher <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> filling pressures reflected by E\/Ea are important causes of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> dysfunction after acute <jats:styled-content style=\"fixed-case\">RVA<\/jats:styled-content> pacing.<\/jats:p>","DOI":"10.1111\/echo.12286","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T20:56:13Z","timestamp":1372884973000},"page":"1042-1050","source":"Crossref","is-referenced-by-count":7,"title":["Left Atrial Responses to Acute Right Ventricular Apical Pacing in Patients with Sick Sinus Syndrome"],"prefix":"10.1111","volume":"30","author":[{"given":"Seong\u2010Man","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Maryknoll Medical Center Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung\u2010Im","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kosin University School of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Joon","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kosin University School of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Ho","family":"Heo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kosin University School of Medicine Busan South 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